| Revue: | Electronic journal of biotechnology |
| Base de datos: | PERIÓDICA |
| Número de sistema: | 000357883 |
| ISSN: | 0717-3458 |
| Autores: | Gontijo, Savio Morato de Lacerda1 Gomes, Alinne Damasia Martins2 Gala-Garcia, Alfonso3 Sinisterra, Ruben Dario2 Cortes, Maria Esperanza3 |
| Instituciones: | 1Universidade Federal de Minas Gerais, Instituto de Ciencias Biologicas, Belo Horizonte, Minas Gerais. Brasil 2Universidade Federal de Minas Gerais, Departamento de Quimica, Belo Horizonte, Minas Gerais. Brasil 3Universidade Federal de Minas Gerais, Departamento de Restauracao Dental, Belo Horizonte, Minas Gerais. Brasil |
| Año: | 2013 |
| Volumen: | 16 |
| Número: | 1 |
| País: | Chile |
| Idioma: | Inglés |
| Tipo de documento: | Artículo |
| Enfoque: | Experimental, aplicado |
| Resumen en inglés | Background: Aloe vera L., member of the Liliaceae family, has been shown to stimulate cell proliferation and contribute to healing and angiogenesis, has anti-bacterial, anti-fungal and anti-inflammatory activity. In addition, Aloe vera can be used as a support for drug transport. Our objective is to evaluate antimicrobial activity and cytotoxicity of sponges of Aloe vera L. for use as a carrying support of drugs. Results: In this work, sponge of free Aloe vera (AV) loaded with amoxicillin (AMX) or nystatin (NYS) at 1% w/w, were prepared and physico-chemically characterized via X-ray diffraction, Fourier Transform Infrared Spectroscopy and thermal analysis. Antimicrobial potency of AV sponge alone, loaded with AMX or NYS, against strains of Streptococcus mutans, Staphylococcus aureus, Aggregatibacter actinomycetemcomitans, Enterococcus faecalis and Candida albicans was determined. Osteoblasts and human gingival fibroblasts were cultivated on AV, Aloe vera loaded with amoxicillin (AV/AMX) and Aloe vera loaded with nystatin (AV/NYS) and cellular viability was assessed. The physico-chemical characterization performed suggested that the loaded drugs were dispersed in the sponge and those interactions between the AV sponge and the loaded drugs were weak. Furthermore, AV loaded with AMX or NYS demonstrated antimicrobial potency and osteoblasts and fibroblasts were viable after 24 hrs on free AV, and AV loaded with AMX or NYS. Conclusions: Our results indicate that sponges of free AV, loaded with AMX or NYS, are biocompatible and exhibit antimicrobial activity |
| Disciplinas: | Biología, Química |
| Palabras clave: | Química farmacéutica, Biotecnología, Excipientes, Amoxicilina, Nistatina, Citotoxicidad, Aloe vera, Liliaceae |
| Keyword: | Biology, Chemistry, Medicinal chemistry, Biotechnology, Excipients, Amoxicillin, Nystatin, Cytotoxicity, Aloe vera, Liliaceae |
| Texte intégral: | Texto completo (Ver HTML) |
