| Revue: | Ecletica quimica |
| Base de datos: | |
| Número de sistema: | 000552422 |
| ISSN: | 0100-4670 |
| Autores: | Cunha, Carlos Eduardo Peixoto1 Rodrigues, Edson Silvio Batista1 Oliveira Neto, Jerônimo Raimundo de1 Somerset, Vernon2 Taveira, Stephânia1 Sgobbi, Lívia Flório3 Gil, Eric de Souza1 |
| Instituciones: | 1Federal University of Goiás, Pharmacy, Goiânia, Brazil., 2Cape Peninsula University of Technology, Faculty of Applied Sciences, Cape Town, South Africa., 3Federal University of Goiás, Chemistry, Goiânia, Brazil., |
| Año: | 2022 |
| Volumen: | 47 |
| Número: | 3 |
| Paginación: | 32-38 |
| País: | Brasil |
| Idioma: | Inglés |
| Resumen en inglés | Doxorubicin (DOX) is an anthracycline antibiotic that is widely used in the clinical treatment of cancer patients. DOX has a high market value. Electroanalytical methods for DOX analysis are an alternative and promising approach compared to chromatographic techniques. In this context, electroanalysis provides a low-cost method for determining drugs such as DOX lyophilized powder for the injection. Differential pulse voltammetry with a glassy carbon electrode was used. DOX stability after reconstitution was performed, and the correct time for safe administration to patients in hospitals was determined. The electroanalytical method showed a limit of detection of 0.54 µmol L‑1 and limit of quantification of 1.83 µmol L–1, which is enough for the application in quality control of DOX. The high-performance liquid chromatography analysis was also applied in pharmaceutical samples containing DOX to compare with the proposed method, showing that the obtained results are relatively similar for both methods. Therefore, the electroanalytical approach shows the viability of an attractive alternative technique for applying this sensor for drug quality control. |
| Keyword: | electrochemistry, quality control of medicines, analytical validation, voltammetry, anticancer drugs |
| Texte intégral: | Texto completo (Ver PDF) |
