| Revue: | Ecletica quimica |
| Base de datos: | |
| Número de sistema: | 000552790 |
| ISSN: | 0100-4670 |
| Autores: | Sartori, Elen Romão1 Barbosa, Nathália Vieira1 Faria, Ronaldo Censi1 Fatibello-Filho, Orlando1 |
| Instituciones: | 1Universidade Federal de São Carlos, Centro de Ciências Exatas e de Tecnologia, São Carlos, Brasil., |
| Año: | 2011 |
| Volumen: | 36 |
| Número: | 1 |
| Paginación: | 110-122 |
| País: | Brasil |
| Idioma: | Inglés |
| Resumen en inglés | In this paper the conductometric titration of propranolol hydrochloride in pharmaceutical formulations using silver nitrate as titrant is proposed. The method was based on the formation of an insoluble salt (AgCl(s)) between the chloride of propranolol hydrochloride molecule and Ag(I) ions of the titrant AgNO3. The effect of the PROP-AgNO3 concentrations and the interval of time between the successive additions of the titrant on the shape of the titration curve were studied. The obtained recoveries for four samples ranged from 96.8 to 105%. The proposed method was successfully applied in the determination of propranolol hydrochloride in several pharmaceutical formulations, with results in close agreement at a 95 % confidence level with those obtained using official spectrophotometric method. |
| Keyword: | conductometric titration, propranolol hydrochloride, silver nitrate, pharmaceutical formulations |
| Texte intégral: | Texto completo (Ver PDF) |
