Chemical, spectroscopic characterization, molecular modeling and antibacterial activity assays of a silver (I) complex with succinic acid
Título del documento: Chemical, spectroscopic characterization, molecular modeling and antibacterial activity assays of a silver (I) complex with succinic acid
Revue: Ecletica quimica
Base de datos:
Número de sistema: 000552484
ISSN: 0100-4670
Autores: 1
3
4
1
5
6
6
7
1
2
Instituciones: 1University of Araraquara, Graduate Program in Biotechnology in Regenerative Medicine and Medicinal Chemistry, Araraquara, Brazil.,
2Federal University of Tocantins, Chemistry Collegiate, Gurupi, Brazil.,
3University of Araraquara, Graduate Program in Biotechnology in Regenerative Medicine and Medicinal Chemistry, Araraquara, Brazil.São Paulo State University, Institute of Chemistry, Araraquara, Brazil.,
4University of Araraquara, Medicine Course, Araraquara, Brazil.,
5São Paulo State University, Institute of Chemistry, Araraquara, Brazil.,
6São Paulo State University, School of Pharmaceutical Sciences, Araraquara, Brazil.,
7University of Campinas, Institute of Chemistry, Campinas, Brazil.,
Año:
Volumen: 46
Número: 2
Paginación: 26-35
País: Brasil
Idioma: Inglés
Resumen en inglés A silver(I) complex with succinic acid in the form of succinate is presented. Chemical characterization confirms the molecular composition Ag2C4H4O4 for the complex. Infrared spectra suggest a bidentate coordination of both carboxylate groups of succinates to the two Ag(I) ions. Density functional theory (DFT) studies were used in the structures of succinic acid and Ag(I) succinate complex with coordination formula [Ag2(C4H4O4)] in order to optimize them to their minimum energy. The studies confirmed that each carboxylate group of the succinate anion is coordinated to one silver atom by the two oxygen in a bidentate mode and the bond lengths O···Ag theoretically determined range from 2.325 to 2.338 Å. The complex [Ag2(C4H4O4)] showed in vitro antibacterial activity against the bacterial strains of Staphylococcus aureus, Bacillus cereus, Escherichia coli and Pseudomonas aeruginosa complex. Anti-Mycobacterium tuberculosis analyses were also performed and the [Ag2(C4H4O4)] complex was shown to be active over M. tuberculosis H37Rv strain with MIC90 of 23.94 μg mL-1 while succinic acid itself showed a value higher than 25.00 μg mL-1.
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