| Revista: | Ecletica quimica |
| Base de datos: | |
| Número de sistema: | 000552800 |
| ISSN: | 0100-4670 |
| Autores: | Vellosa, José Carlos Rebuglio1 Regasini, Luiz Octávio2 Maissar Khalil, Najeh3 Silva Bolzani, Vanderlan da2 Kalil, Omar Arafat Kdudsi4 Manente, Francine Alessandra1 Netto, Harli Pasquini1 Oliveira, Olga Maria Mascarenhas de Faria2 |
| Instituciones: | 1Universidade Estadual de Ponta Grossa, Departamento de Ciências Farmacêuticas, Ponta Grossa, Paraná. Brasil 2Universidade Estadual Paulista "Júlio de Mesquita Filho", Instituto de Química, Araraquara, São Paulo. Brasil 3Universidade Estadual do Centro Oeste, Departamento de Farmácia, Guarapuava, Paraná. Brasil 4Instituto Federal de Goiás, Formosa, Goiás. Brasil |
| Año: | 2011 |
| Volumen: | 36 |
| Número: | 2 |
| Paginación: | 07-20 |
| País: | Brasil |
| Idioma: | Inglés |
| Tipo de documento: | Artículo |
| Resumen en inglés | The aim of the present study was to investigate a cytotoxic oxidative cell stress related and the antioxidant profile of kaempferol, quercetin, and isoquercitrin. The flavonol compounds were able to act as scavengers of superoxide anion (but not hydrogen peroxide), hypochlorous acid, chloramine and nitric oxide. Although flavonoids are widely described as antioxidants and this activity is generally related to beneficial effects on human health, here we show important cytotoxic actions of three well known flavonoids. They were able to promote hemolysis which one was exacerbated on the presence of hypochlorous acid but not by AAPH radical. Therefore, despite they expected scavenger action over free radicals an oxidants, these compounds could be very lesive to living organisms by acting over erythrocytes and maybe other cellular types. |
| Disciplinas: | Química, Química |
| Palabras clave: | Química orgánica, Química farmacéutica |
| Keyword: | Organic chemistry, Medicinal chemistry |
| Texto completo: | Texto completo (Ver PDF) |
