Exposición prenatal a drogas de abuso. Efectos diferidos e imprinting (desprogramación celular)



Título del documento: Exposición prenatal a drogas de abuso. Efectos diferidos e imprinting (desprogramación celular)
Revue: Cuadernos médico sociales (Santiago)
Base de datos: PERIÓDICA
Número de sistema: 000349166
ISSN: 0716-1336
Autores: 1
1
1
Instituciones: 1Universidad de Chile, Facultad de Medicina, Santiago de Chile. Chile
Año:
Periodo: Dic
Volumen: 49
Número: 4
Paginación: 254-265
País: Chile
Idioma: Español
Tipo de documento: Artículo
Enfoque: Descriptivo
Resumen en español suaves como los cannabinoides, es fundamental para proteger la salud de las futuras generaciones. Adicionalmente, se presenta evidencia que la exposición prenatal a contaminantes ambientales es una condición que aumenta de por vida la sensibilidad para desarrollar adicciones a drogas de abuso, lo cual indica la importancia de implementar medidas para controlar la contaminación ambiental como una herramienta en la lucha contra el uso de drogas de abuso
Resumen en inglés The use of drugs of abuse is a serious health and social problem through all the world. The ef ects of acute and chronic exposure of drugs of abuse on health are well known. They also cause direct ef ects on placenta o the developing embryo organs, causing congenital malformations. There is however very scarce information on the delayed ef ects of exposure to these agents during the last stages of fetal development or the early stages of postnatal development. These agents cause irreversible alterations in cell dif erentiation and programming, that could be considered as biochemical and functional malformations, responsible of functional organic or neurobehavioral alterations that favors the development of diseases later in life. The present report describes persistent ef ects of prenatal exposure to illicit drugs of abuse (opiates, cocaine, ketamine, toluene, cannabinoids, and amphetamine derivates) and to legal drugs of abuse (ethyl alcohol; nicotine and tobacco smoking are not reviewed since they were analyzed in a previous publication in Cuadernos). Exposure to these agents favors the development of a myriad of diseases and behavioral alterations later in life. In addition, evidence is presented that prenatal exposure to various chemicals (lead, the pesticide malathion, bisphenol) and several drugs of abuse (opioids, ethanol, cannabinoids) determine persistent changes that favor the development of addictions to drugs of abuse later in life. It is concluded that, besides the known health and social problems derived by adults use of drugs of abuse, fetal exposure causes changes that determine the development of various diseases later in life, including drug addiction. Therefore, the dictation of Governmental regulations to decrease access to and use of these drugs, including the “softest” drugs such as cannabinoids, is fundamental to protect future generations health. In addition, evidence is presented that environmental pollutant prenatal..
Disciplinas: Medicina,
Educación
Palabras clave: Salud pública,
Toxicología,
Consumo de drogas,
Embarazo,
Contaminación ambiental,
Feto,
Adicciones,
Ketamina,
Cocaína,
Tolueno,
Opioides
Keyword: Medicine,
Education,
Public health,
Toxicology,
Drug consumption,
Pregnancy,
Environmental pollution,
Fetus,
Addictions,
Cocaine,
Ketamine,
Toluene,
Opioids
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