| Revue: | Brazilian Journal of Pharmaceutical Sciences |
| Base de datos: | PERIÓDICA |
| Número de sistema: | 000451931 |
| ISSN: | 1984-8250 |
| Autores: | Mansour, Suzan Mohamed1 Ibrahim, Rasha Youssef Mohammed2 |
| Instituciones: | 1Cairo University, Faculty of Pharmacy, El Cairo. Egipto 2Atomic Energy Authority Nuclear Research Centre, Department of Radioisotopes, El Cairo. Egipto |
| Año: | 2022 |
| Volumen: | 58 |
| País: | Brasil |
| Idioma: | Inglés |
| Tipo de documento: | Artículo |
| Enfoque: | Experimental, aplicado |
| Resumen en inglés | Angiotensin-II (AgII) is thought to be crucial for tumor growth and progression. Moreover, hydrogen sulfide (H2S) performs a controversial action in cancer pathology. Zofenopril (ZF) is an angiotensin-converting enzyme (ACE) inhibitor with H2S donating properties. Hence, this study aims at investigating the tumor suppressor activity of ZF and elucidating the involved trajectories in Ehrlich’s solid tumor (EST)-bearing mice. EST was induced by the intradermal injection of Ehrlich’s ascites carcinoma cells into femoral region. All parameters were assessed after 28 days post-inoculation or one-week thereafter. ZF treatment resulted in significant reduction of tumor weights with marked decrease in IL-6 and VEGF levels in serum, and tumor Ag II and CEA contents. Additionally, the administration of ZF downregulated the tumor gene expression of cyclin-D, ACE-1, and Bcl2 and upregulated the proapoptotic gene, BAX. Moreover, ZF increased CBS gene expression, which is a major contributor to cellular H2S production. In addition, ZF was able to reduce the protein expression of PI3K, pAKT, pGSK-3β, and NFκB. Our study has provided novel insights into the possible mechanisms by which ZF may produce its tumor defeating properties. These intersecting trajectories involve the interference between PI3K/Akt and CBS signaling pathways |
| Disciplinas: | Medicina |
| Palabras clave: | Oncología, Farmacología, Medicina experimental, Zofenopril, Actividad antitumoral, Angiotensina II, Sulfuro de hidrógeno, Cistationina beta sintetasa |
| Keyword: | Oncology, Pharmacology, Experimental medicine, Zofenopril, Antitumoral activity, Angiotensin II, Hydrogen sulfide, Cystathionine beta synthase |
| Texte intégral: | Texto completo (Ver HTML) Texto completo (Ver PDF) |
