| Revue: | Brazilian Journal of Pharmaceutical Sciences |
| Base de datos: | PERIÓDICA |
| Número de sistema: | 000451230 |
| ISSN: | 1984-8250 |
| Autores: | Elfahmi1 Chahyadi, Agus2 |
| Instituciones: | 1Institut Teknologi Bandung, The School of Pharmacy, Bandung, West Java. Indonesia 2Institut Teknologi Bandung, University Centre of Excellence for Nutraceutical, Bioscience and Biotechnology Research Centre, Bandung, West Java. Indonesia |
| Año: | 2020 |
| Volumen: | 56 |
| País: | Brasil |
| Idioma: | Inglés |
| Tipo de documento: | Artículo |
| Enfoque: | Aplicado, descriptivo |
| Resumen en inglés | Ursodeoxycholic acid (UDCA), a secondary bile acid (BA), has been used as a drug to treat various liver diseases. UDCA is synthesised from cholic or chenodeoxycholic acid (CA/CDCA), two primary BAs frequently used as the starting materials. Nowadays, swine, cattle, and poultry bile are the main sources of those BAs. However, other commercial animals could be promising sources as well. We identified two livestock, two poultries, and eight fishes that are commercially cultivated in Indonesia. Four free BAs including CA, CDCA, deoxycholic acid (DCA), and lithocholic acid (LA) were identified for their occurrences using thin-layer chromatography and high-performance liquid chromatography. CA was detected in cow, duck, red tilapia, gourami, the common carp, and grouper, whereas CDCA was only detected in two poultries and the common carp. The occurrence of DCA was common and abundant in most tested animals. In contrast, the presence of LA was found to be very low in all samples. The biliary bile of tilapia has been found to contain a high abundance of free CA (43% of the total bile). A simple extraction was able to purify CA from biliary bile of tilapia. This is a new promising and competitive source of CA |
| Disciplinas: | Química |
| Palabras clave: | Química farmacéutica, Precursores químicos, Acido ursodeoxicólico, Acidos biliares |
| Keyword: | Medicinal chemistry, Chemical precursors, Ursodeoxycholic acid, Bile acids |
| Texte intégral: | Texto completo (Ver HTML) Texto completo (Ver PDF) |
