The benefit of Silybum marianum in ethanol-induced reprotoxicity of male Wistar rat



Título del documento: The benefit of Silybum marianum in ethanol-induced reprotoxicity of male Wistar rat
Revue: Brazilian Journal of Pharmaceutical Sciences
Base de datos: PERIÓDICA
Número de sistema: 000452108
ISSN: 1984-8250
Autores: 1
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Instituciones: 1University Badji Mokhtar-Annaba, Faculty of Sciences, Annaba. Argelia
Año:
Volumen: 58
País: Brasil
Idioma: Inglés
Tipo de documento: Artículo
Enfoque: Experimental, aplicado
Resumen en inglés This study investigates the toxic effects of ethanol (Eth) on the reproductive system of male rats and the possible protective role of Silybum marianum seeds-infused solution (SMI) over six consecutive weeks of administration. Animals were divided into the following groups: control, SMI positive control (200 mg/kg/day), Eth1 (1 g/kg/day), Eth2 (2 g/kg/day), Eth1+SMI, and Eth2+SMI. Plasma testosterone concentration, epididymal spermatozoa biology, and testicular and epididymal MDA, GSH and GPx levels were evaluated. The results indicated a significant decrease in testis and epididymis weight, testosterone level, sperm concentration, sperm vitality and sperm motility (total motility, progressive motility, curvilinear velocity, straight-line velocity, velocity average path, beat cross frequency, and lateral head displacement) in both Eth1 and Eth2 compared to the control groups and the combined-treatment groups (Eth1+SMI and Eth2+SMI). Furthermore, results showed a significant elevation in MDA concentration with a significant decrease of testicular and epididymal GSH concentration and GPx activity in theEth1 and Eth2 groups compared to the combined-treatment groups. The administration of SMI succeeded in improving the parameters cited above in the combined-treatment groups compared to the Eth1 and Eth2 groups, and bring them to the levels seen in the control groups. To conclude, SMI has clearly protected reproductive indices against ethanol-induced reprotoxicity in male rats
Disciplinas: Biología,
Química
Palabras clave: Fitoquímica,
Reproducción y desarrollo,
Extractos vegetales,
Infertilidad masculina,
Protección química,
Espermatozoides,
Ratas,
Silybum marianum,
Asteraceae
Keyword: Phytochemistry,
Reproduction and development,
Plant extracts,
Male infertility,
Chemical protection,
Spermatozoa,
Rats,
Silybum marianum,
Asteraceae
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