Revista: | Brazilian Journal of Pharmaceutical Sciences |
Base de datos: | PERIÓDICA |
Número de sistema: | 000451925 |
ISSN: | 1984-8250 |
Autores: | Tay, Naime Funda1 Duran, Murat1 Kayagil, İsmail2 Yurttaş, Leyla3 Göger, Gamze4 Göger, Fatih3 Demirci, Fatih3 Demirayak, Şeref5 |
Instituciones: | 1Eskisehir Osmangazi University, Faculty of Science and Letters, Eskisehir. Turquía 2Burdur Mehmet Akif Ersoy University, Faculty of Arts & Science, Burdur. Turquía 3Anadolu University, Faculty of Pharmacy, Eskisehir. Turquía 4Trakya University, Faculty of Pharmacy, Edirne. Turquía 5Medipol University, School of Pharmacy, Estambul. Turquía |
Año: | 2022 |
Volumen: | 58 |
País: | Brasil |
Idioma: | Inglés |
Tipo de documento: | Artículo |
Enfoque: | Experimental, aplicado |
Resumen en inglés | In this present study, 63 different 5-[4-methyl-2-(pyridin-3/4-yl)thiazole-5-yl]-4-substituted-3-substituted benzylthio-4H-1,2,4-triazole derivatives were synthesized, and evaluated for their in vitro antimicrobial activity against various human pathogenic microorganisms and antioxidant activity. The derivatives were synthesized in a multi-step synthesis procedure including triazole and thiazole ring closure reactions, respectively. The synthesized derivatives (A1-24; B1-39) were screened for their antibacterial, antifungal, and antioxidant activities compared to standard agents. The derivatives possessing 3-pyridyl moiety particularly exhibited relatively high antibacterial activity (MIC= < 3.09-500 µg/mL) against Gram-positive bacteria, and compounds possessing 4-pyridyl moiety showed remarkable antioxidant activity |
Disciplinas: | Química |
Palabras clave: | Química farmacéutica, Triazoles, Tiazoles, Piridina, Actividad antimicrobiana, Actividad antioxidante, Secuestro químico |
Keyword: | Medicinal chemistry, Triazole, Thiazoles, Pyridine, Antimicrobial activity, Antioxidant activity, Chemical scavenging |
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