S-allyl Cysteine and Taurine revert peripheral metabolic and lipid profile in non-insulin-dependent diabetes mellitus animals: Combination vs Monotherapy
Título del documento: S-allyl Cysteine and Taurine revert peripheral metabolic and lipid profile in non-insulin-dependent diabetes mellitus animals: Combination vs Monotherapy
Revue: Brazilian Journal of Pharmaceutical Sciences
Base de datos: PERIÓDICA
Número de sistema: 000451827
ISSN: 1984-8250
Autores: 1
2
3
2
4
5
Instituciones: 1Bhagwant University, Department of Pharmacy, Ajmer, Rajastan. India
2Aligarh Muslim University, Interdisciplinary Biotechnology Unit, Aligarh, Uttar Pradesh. India
3Vivek College of Technical Education, Department of Pharmacy, Bijnor, Uttar Pradesh. India
4SUMER, Department of kulliyat, Jamia Hamdard, New Delhi. India
5Goel Institute of Pharmaceutical Sciences, Lucknow, Uttar Pradesh. India
Año:
Volumen: 58
País: Brasil
Idioma: Inglés
Tipo de documento: Artículo
Enfoque: Experimental, aplicado
Resumen en inglés The present study was designed to evaluate the beneficial synergistic effects of S-allyl Cysteine (SAC) and Taurine (TAU) on hyperglycemia, lipid profile and renal damage markers in type 2 diabetes mellitus (T2DM) in rats. Experimental T2DM was developed by administering an intraperitoneal single dose of nicotinamide (NA; 230 mg/kg) and streptozotocin (STZ; 65 mg/ kg) in adult rats. Control and diabetic rats were treated with SAC (150 mg/kg); TAU (200 mg/ kg) or SAC and TAU (75+100 mg/kg) combination for four weeks. Measurements of traditional markers of kidney toxicity in serum, such as blood urea nitrogen (BUN), serum creatinine (Scr), and alkaline phosphatase (ALP), together with serum cholesterol/triglyceride such as serum total cholesterol (TC), triglycerides (TG), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C) and very low-density lipoprotein cholesterol (VLDL-C) may yield a snapshot of renal damage and lipid profile in NA/STZ-treated rats. The variation in levels of fasting blood glucose, glycosylated hemoglobin, insulin and lipid profile was significantly augmented in SAC/TAU treatment group. The diabetic group showed elevated renal injury markers in serum, which were decreased significantly by SAC/TAU treatment. Thus the results of the experiment clearly indicate the potential of the SAC/TAU combination in improving diabetic complications
Disciplinas: Medicina
Palabras clave: Endocrinología,
Farmacología,
Diabetes mellitus tipo 2,
Hiperlipidemia,
Daño renal,
Sinergismo,
S-alil cisteína,
Taurina
Keyword: Endocrinology,
Pharmacology,
Diabetes mellitus type 2,
Hyperlipidemia,
Synergism,
S-allyl cysteine,
Taurine,
Renal damage
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