| Revue: | Brazilian Journal of Pharmaceutical Sciences |
| Base de datos: | PERIÓDICA |
| Número de sistema: | 000451771 |
| ISSN: | 1984-8250 |
| Autores: | Goyal, Ahsas1 Agrawal, Neetu1 Jain, Ankit2 Gupta, Jeetendra Kumar1 Garabadu, Debapriya1 |
| Instituciones: | 1GLA University, Institute of Pharmaceutical Research, Mathura, Uttar Pradesh. India 2Dr. Hari Singh Gour Central University, Department of Pharmaceutical Sciences, Sagar, Madhya Pradesh. India |
| Año: | 2022 |
| Volumen: | 58 |
| País: | Brasil |
| Idioma: | Inglés |
| Tipo de documento: | Artículo |
| Enfoque: | Experimental, aplicado |
| Resumen en inglés | Caveolin, the protein of the caveolar membrane, interacts and binds with endothelial nitric oxide synthase (eNOS), forming a caveolin-eNOS complex leading to suppression of the eNOS activity. Caveolin, therefore, maintains eNOS in the inactivated state leading to reduced nitric oxide (NO) production. Ischemic preconditioning disrupts the caveolin-eNOS complex leading to activation of the eNOS and thus results in cardioprotection. During ischemic preconditioning, NO produces cardioprotection by the opening of the KATP channel, and the caveolin forms a suitable signalling platform facilitating the interaction of NO with the KATP channel. Estrogen deficiency has been reported to upregulate caveolin-1 expression. The article aims to review the various mechanisms that placed the women at the risk of coronary artery diseases after postmenopausal estrogen deficiency and their role in the cardioprotective effect of ischemic preconditioning |
| Disciplinas: | Medicina |
| Palabras clave: | Sistema cardiovascular, Caveolin, Cardioprotección, Oxido nítrico, Precondicionamiento isquémico, Postmenopausia |
| Keyword: | Cardiovascular system, Caveolin, Cardioprotection, Nitric oxide, Ischemic preconditioning, Postmenopause |
| Texte intégral: | Texto completo (Ver HTML) Texto completo (Ver PDF) |
