| Revue: | Brazilian Journal of Pharmaceutical Sciences |
| Base de datos: | PERIÓDICA |
| Número de sistema: | 000452213 |
| ISSN: | 1984-8250 |
| Autores: | Asgharian, Shirin1 Lorigooini, Zahra1 Bijad, Elham1 Hosseinkhani, Hasan1 Abbasian, Zahra1 Rafieian Kopaei, Mahmoud1 |
| Instituciones: | 1Shahrekord University of Medical Sciences, Basic Health Sciences Institute, Shahrekord. Irán |
| Año: | 2022 |
| Volumen: | 58 |
| País: | Brasil |
| Idioma: | Inglés |
| Tipo de documento: | Artículo |
| Enfoque: | Experimental, aplicado |
| Resumen en inglés | The effects of Rheum ribes on lead acetate levels and hepatic biochemical factors due to lead acetate toxicity were investigated. Forty male Wistar rats were designated into four groups: Control; lead acetate (receiving in drinking water at 0.6 g/L, daily); hydroalcoholic extract groups (200 and 400 mg/kg doses, gavage, once daily). Treatments were conducted for 10 days. On the 11th day, blood samples were collected to measure lead acetate levels and biochemical factors. Liver tissue samples were examined for histopathological changes. Lead serum levels were increased in lead acetate-treated rats (p<0.001). Lead acetate treatment was associated with a significant increase in liver tissue damage (p<0.001), while R. ribes extract prevented liver tissue damage (p<0.05). The levels of alanine aminotransferase and aspartate aminotransferase were significantly lower in the groups lead acetate + extract (two doses) than in the lead acetate group (p<0.001 and P<0.01, respectively), but alkaline phosphatase level, prothrombin time, partial thromboplastin time and international normalized ratio were not different between the lead acetate + extract groups and the lead acetate group. The results showed the inhibitory role of R. ribes on lead-induced hepato-toxicity. The results make Rhubarb a good candidate to protect against the deleterious effect of chronic lead intoxication after complementary studies |
| Disciplinas: | Química |
| Palabras clave: | Fitoquímica, Farmacología, Extractos vegetales, Hepatoprotección, Hepatotoxicidad, Acetato de plomo, Rheum ribes, Polygonaceae, Ratas |
| Keyword: | Phytochemistry, Pharmacology, Plant extracts, Hepatoprotection, Hepatotoxicity, Lead acetate, Rheum ribes, Polygonaceae, Rats |
| Texte intégral: | Texto completo (Ver HTML) Texto completo (Ver PDF) |
