| Revue: | Brazilian Journal of Pharmaceutical Sciences |
| Base de datos: | PERIÓDICA |
| Número de sistema: | 000451787 |
| ISSN: | 1984-8250 |
| Autores: | Nguyen, Tu Thanh Thi1 Do, Phuong Thi1 Pham, Anh Van Thi2 Nguyen, Huong Giang Thi Tran2 Nguyen, Lan Ngoc Thi3 Nguyen, Trang Tuyet1 |
| Instituciones: | 1Hanoi Medical University, Traditional Medicine Faculty, Hanoi. Vietnam 2Hanoi Medical University, Department of Pharmacology, Hanoi. Vietnam 3Hanoi Medical University, Department of Internal Medicine, Hanoi. Vietnam |
| Año: | 2022 |
| Volumen: | 58 |
| País: | Brasil |
| Idioma: | Inglés |
| Tipo de documento: | Artículo |
| Enfoque: | Experimental, aplicado |
| Resumen en inglés | The phytochemical investigation on Vitex negundo leaves has led to the isolation of one new iridoid glucoside (8α-hydroxy-4-carboxyl-5βH-9βH-iridoid-1α-O-(6′-O-(6,7-dihydrofoliamenthonyl)-β-ᴅ-glucopyranoside, 3), together with three known compounds, namely agnuside (1), 6′-O-E-caffeoylmussaenosidic acid (2), and 3,5-dicaffeoylquinic acid (4). The HPLC analytical study was also performed to quantify the content of agnuside (1) in dried leaves. The results indicated the very high content of 1 (3.04 ± 0.02%). The method was also validated by various parameters, including linearity (R2= 0.9999), precision (intra-day RSD ≤ 2.50%, inter-day RSD= 0.76%), and accuracy (recovery rates 96.58-101.86%). The animal testing data showed that the extract did not reduce pain at the doses of 9.6 and 28.8 g /kg (leaf weight/body weight) in the hot plates and pain measuring models but showed the pain reduction in the acetic acid-induced pain model. The extract at the dose of 5.6 g/kg (leaf weight/body weight) also had effects on the acute inflammation in the carrageenin-induced edema model. The extract at the dose 9.6 and 28.8 g/kg (leaf weight/body weight) also showed significant chronic anti-inflammation, comparable to methylprednisolone at the dose 10 mg/kg on the mouse peritoneal |
| Disciplinas: | Biología, Química |
| Palabras clave: | Fitoquímica, Angiospermas, Glucósidos iridoideos, Actividad antiinflamatoria, Actividad analgésica, Vitex negundo, Lamiaceae |
| Keyword: | Phytochemistry, Angiosperms, Iridoids glucosides, Anti-inflammatory activity, Analgesic activity, Vitex negundo, Lamiaceae |
| Texte intégral: | Texto completo (Ver HTML) Texto completo (Ver PDF) |
