| Revue: | Brazilian Journal of Pharmaceutical Sciences |
| Base de datos: | PERIÓDICA |
| Número de sistema: | 000451824 |
| ISSN: | 1984-8250 |
| Autores: | Chu, Zixuan1 Lu, Min1 Liu, Teng1 Xiong, Shan1 Mu, Yanling1 |
| Instituciones: | 1Shandong First Medical University, School of Pharmacy and Pharmaceutical Sciences, Jinan, Shandong. China |
| Año: | 2022 |
| Volumen: | 58 |
| País: | Brasil |
| Idioma: | Inglés |
| Tipo de documento: | Artículo |
| Enfoque: | Experimental, aplicado |
| Resumen en inglés | To investigate the pharmacokinetics and pharmacodynamics of Astragali Radix-Corni Fructus herb-pair in kidney-yin deficiency model, which was made by continuously oral gavage of thyroxine. A simple and rapid LC-MS/MS method was developed and validated for the determination of loganin and morroniside in rat plasma and used for the pharmacokinetics study. The kidney-yin deficiency significantly changed the AUC(0-∞), Cmax and CLz/F of loganin and morroniside. The T1/2z of morroniside increased significantly in the kidney-yin deficiency rats. For the pharmacodynamics study, the liver index, kidney index, and ALT, TBIL, UREA, CREA level in the kidney-yin deficiency mice were examined. The herb-pair had been proved to be effective for the treatment of kidney-yin deficiency by affecting the liver, kidney, ALT, UREA and CREA, which showed positively correlated with the dose. The pharmacokinetics and pharmacodynamics studies in the pathological status could offer more valuable information for the future application of Astragali Radix-Corni Fructus herb-pair |
| Disciplinas: | Química, Medicina |
| Palabras clave: | Nefrología, Farmacología, Insuficiencia renal, Plantas medicinales, Farmacodinamia, Farmacocinética, Astragalus membranaceus, Fabaceae |
| Keyword: | Nephrology, Pharmacology, Renal failure, Medicinal plants, Pharmacodynamics, Pharmacokinetics, Astragalus membranaceus, Fabaceae |
| Texte intégral: | Texto completo (Ver HTML) Texto completo (Ver PDF) |
