New topical microemulsions of etofenamate as sufficient management of osteoarthritis
Título del documento: New topical microemulsions of etofenamate as sufficient management of osteoarthritis
Revue: Brazilian Journal of Pharmaceutical Sciences
Base de datos: PERIÓDICA
Número de sistema: 000451765
ISSN: 1984-8250
Autores: 1
2
3
3
Instituciones: 1University of Health Sciences, Faculty of Pharmacy, Estambul. Turquía
2Ege University, School of Pharmacy, Izmir. Turquía
3Yeditepe University, School of Pharmacy, Estambul. Turquía
Año:
Volumen: 58
País: Brasil
Idioma: Inglés
Tipo de documento: Artículo
Enfoque: Experimental, aplicado
Resumen en inglés In this study, microemulsions containing etofenamate were prepared and evaluated as dermal delivery carriers. The developed microemulsions consist of oleic acid, Span 80, Tween 20, Cremophor EL, Transcutol and ethanol. The percentage of etofenamate loading in the microemulsions was 5% (w/w). The characterization of formulations included droplet size, zeta potential, pH, conductivity, PDI, refractive index and viscosity. Moreover, ex vivo penetration study was carried out using mice abdominal skin. The developed formulations were analyzed for their cytotoxicity via MTT assay and tested for their anti-inflammatory properties opposed to LPS-stimulated nitrite prοduction in RAW 264.7 cells. As ideal formulation, M2ETF, was chosen due to its greater permeation, lower penetration as well as higher anti-inflammatory activity compared to other microemulsions
Disciplinas: Medicina
Palabras clave: Reumatología,
Farmacología,
Osteoartritis,
Antiinflamatorios no esteroideos,
Microemulsiones,
Citotoxicidad,
Etofenamato
Keyword: Rheumatology,
Pharmacology,
Osteoarthritis,
Non steroidal antinflammatory drugs,
Microemulsions,
Cytotoxicity,
Etofenamate
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