| Revue: | Brazilian Journal of Pharmaceutical Sciences |
| Base de datos: | PERIÓDICA |
| Número de sistema: | 000451442 |
| ISSN: | 1984-8250 |
| Autores: | Cardoso, Priscylla Maria Martins1 Mazuco, Renata Alves1 Macedo, Lucas Soares Dazzi1 Polese, Ariele Abreu Venturini1 Barroso, Maria Eduarda de Souza1 Baratella, Waléria Gramilich1 Andrade, Tadeu Uggere de1 Lenz, Dominik1 Pereira, Thiago de Melo Costa1 Endringer, Denise Coutinho1 |
| Instituciones: | 1Universidade Vila Velha, Programa de Ciencias Farmaceuticas, Vila Velha, Espirito Santo. Brasil |
| Año: | 2020 |
| Volumen: | 56 |
| País: | Brasil |
| Idioma: | Inglés |
| Tipo de documento: | Artículo |
| Enfoque: | Experimental, aplicado |
| Resumen en inglés | Contrast-induced nephropathy (NIC) is directly related to increased morbidity and mortality, and its treatment and prevention might be achieved by the administration of antioxidant products. The juçara palmetto (Euterpe edulis Martius) has fruits rich in phenolic compounds, which are known for their antioxidant activity. This work aimed to evaluate the nephroprotective activity of E. edulis pulp in the NIC animal model. The collected fruits were pulped, their contents of polyphenols and anthocyanins were quantified, and their antioxidant activity were evaluated. The nephroprotective effects were determined based on iodine contrast induction and evaluated by biochemical and histological analyses. The results showed that E. edulis pulp was rich in polyphenols (811 ± 16.7 mg EAG/g) and anthocyanins (181.25 mg/100 g) and had very strong antioxidant activity, as demonstrated by the DPPH (2,2-diphenyl-1-picryl-hydrazyl) method, which revealed an antioxidant activity index (AAI) of 3.4, and the 2,29-azinobis (3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) method, which revealed an IC50 of 0.59 ± 0.03 mg/mL. In the in vivo experiments, E. edulis pulp tended to provide renal protection and reduce renal dysfunction and tubular morphological lesions in mice after the induction of NIC, and these effects were obtained through the antioxidant activities of the polyphenols in the pulp |
| Disciplinas: | Química, Biología |
| Palabras clave: | Angiospermas, Fitoquímica, Farmacología, Polifenoles, Antocianinas, Actividad antioxidante, Nefroprotección, Euterpe edulis, Arecaceae |
| Keyword: | Angiosperms, Phytochemistry, Pharmacology, Polyphenols, Anthocyanins, Antioxidant activity, Nephroprotection, Euterpe edulis, Arecaceae |
| Texte intégral: | Texto completo (Ver HTML) Texto completo (Ver PDF) |
