| Revue: | Brazilian Journal of Pharmaceutical Sciences |
| Base de datos: | PERIÓDICA |
| Número de sistema: | 000451564 |
| ISSN: | 1984-8250 |
| Autores: | Borges, Gabriel Silva Marques1 Prazeres, Pedro Henrique Dias Moura2 Souza, Ângelo Malachias de3 Yoshida, Maria Irene3 Vilela, José Mario Carneiro4 Silva, Aline Teixeira Maciel e1 Oliveira, Mariana Silva1 Gomes, Dawidson Assis2 Andrade, Margareth Spangler4 Souza Fagundes, Elaine Maria de2 Ferreira, Lucas Antonio Miranda1 |
| Instituciones: | 1Universidade Federal de Minas Gerais, Faculdade de Farmacia, Belo Horizonte, Minas Gerais. Brasil 2Universidade Federal de Minas Gerais, Instituto de Ciencias Biologicas, Belo Horizonte, Minas Gerais. Brasil 3Universidade Federal de Minas Gerais, Instituto de Ciencias Exatas, Belo Horizonte, Minas Gerais. Brasil 4Servico Nacional de Aprendizajem Industrial, Centro de Inovacao e Tecnologia, Belo Horizonte, Minas Gerais. Brasil |
| Año: | 2021 |
| Volumen: | 57 |
| País: | Brasil |
| Idioma: | Inglés |
| Tipo de documento: | Artículo |
| Enfoque: | Experimental, aplicado |
| Resumen en inglés | Sclareol (SC) is arousing great interest due to its cytostatic and cytotoxic activities in several cancer cell lines. However, its hydrophobicity is a limiting factor for its in vivo administration. One way to solve this problem is through nanoencapsulation. Therefore, solid lipid nanoparticles (SLN-SC) and nanostructured lipid carriers (NLC-SC) loaded with SC were produced and compared regarding their physicochemical properties. NLC-SC showed better SC encapsulation than SLN-SC and was chosen to be compared with free SC in human cancer cell lines (MDA-MB-231 and HCT-116). Free SC had slightly higher cytotoxicity than NLC-SC and produced subdiploid DNA content in both cell lines. On the other hand, NLC-SC led to subdiploid content in MDA-MB-231 cells and G2/M checkpoint arrest in HCT-116 cells. These findings suggest that SC encapsulation in NLC is a way to allow the in vivo administration of SC and might alter its biological properties |
| Disciplinas: | Química, Medicina |
| Palabras clave: | Química farmacéutica, Oncología, Esclareol, Sistemas de liberación de fármacos, Nanopartículas lípidas sólidas, Acarreadores lipídicos, Dispersión de rayos X en ángulos pequeños |
| Keyword: | Medicinal chemistry, Oncology, Sclareol, Drug delivery systems, Solid lipid nanoparticles, Lipid carriers, Small angle x-ray scattering |
| Texte intégral: | Texto completo (Ver HTML) Texto completo (Ver PDF) |
