Leaf extract of Coffea arabica L. reduces lipid peroxidation and has anti-platelet effect in a rat dyslipidemia model



Título del documento: Leaf extract of Coffea arabica L. reduces lipid peroxidation and has anti-platelet effect in a rat dyslipidemia model
Revue: Brazilian Journal of Pharmaceutical Sciences
Base de datos: PERIÓDICA
Número de sistema: 000451901
ISSN: 1984-8250
Autores: 1
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Instituciones: 1Universidade Federal de Alfenas, Colegio de Ciencias Farmaceuticas, Alfenas, Minas Gerais. Brasil
2Universidade Federal de Alfenas, Instituto de Ciencias Biomedicas, Alfenas, Minas Gerais. Brasil
3Universidade Federal de Alfenas, Instituto de Ciencias Exatas, Alfenas, Minas Gerais. Brasil
Año:
Volumen: 58
País: Brasil
Idioma: Inglés
Tipo de documento: Artículo
Enfoque: Experimental, aplicado
Resumen en inglés This study aimed to evaluate the antioxidant potential of the Coffea arabica Lineu (L.) leaf extract and its effects on platelet aggregation of dyslipidemic rats. The extract was obtained by the percolation of C. arabica L. leaves in hydroethanolic solution 70% (v/v). The mass spectrometry FIA-ESI-MS² suggested the presence of chlorogenic acid, rutin acid, and quinic acid. The DPPH• radicals scavenging capacity was demonstrated (IC50 = 0.06 mg/mL). The extract was administered to rats by gavage (300 mg/kg/day) for 56 days. Dyslipidemia was induced by administering Triton WR-1339 (300 mg/kg body weight) on the 54th day. On day 56, blood was collected by puncturing the abdominal aorta artery and the aortic artery was removed. Lipid profile, markers of renal and hepatic injury, lipid peroxidation, and platelet aggregation tests were carried out. The ingestion of extract reduced the lipid peroxidation (aorta and plasma) and platelet aggregation in dyslipidemic rats. The extract did not affect markers of renal and hepatic function as analyzed in this study, suggesting neither impaired liver nor kidney function in these animals. Therefore, our results demonstrate that the extract of leaves of C. arabica L. show antioxidant potential in vitro and in vivo as well as anti-platelet aggregation in dyslipidemic animals
Disciplinas: Medicina
Palabras clave: Farmacología,
Medicina experimental,
Café,
Antioxidantes,
Dislipidemia,
Peroxidación lipídica,
Agregación plaquetaria
Keyword: Pharmacology,
Experimental medicine,
Coffee,
Antioxidants,
Dyslipidemia,
Lipid peroxidation,
Platelet aggregation
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