| Revue: | Brazilian Journal of Pharmaceutical Sciences |
| Base de datos: | PERIÓDICA |
| Número de sistema: | 000451927 |
| ISSN: | 1984-8250 |
| Autores: | Okekunle, Mary Oluwaseun1 Akin Ajani, Olufunke Dorothy2 Ekpukpon, Bridget Lucy2 Odeku, Oluwatoyin Adepeju2 Olu Owolabi, Bamidele Iromidayo1 Adebowale, Kayode Oyebode1 |
| Instituciones: | 1University of Ibadan, Faculty of Science, Ibadan, Western. Nigeria 2University of Ibadan, Faculty of Pharmacy, Ibadan, Western. Nigeria |
| Año: | 2022 |
| Volumen: | 58 |
| País: | Brasil |
| Idioma: | Inglés |
| Tipo de documento: | Artículo |
| Enfoque: | Experimental, aplicado |
| Resumen en inglés | Red lima bean (Phaseolus lunatus Linn) Family Fabaceae, has been modified by succinylation and annealing, and used as intra- and extra-granular disintegrants at concentrations of 5 and 10 %w/w in paracetamol tablet formulation in comparison with corn starch BP. The starches were characterised using FT-IR spectroscopy, SEM, proximate analysis, physicochemical and functional properties. FT-IR spectrometry revealed characteristic peaks at 1575.53 and 1713.99 cm-1 for the succinylated starch while the annealed showed no significant difference from the native starch. Modifications did not alter the ovoid shape of the native starch but reduced the particle size. Succinylation improved water absorption capacity, solubility and swelling of lima bean starch but annealing reduced the parameters. Tablets with disintegrants of lima bean starches generally had higher crushing strengths and lower friability than tablets with corn starch. Modifications reduced the disintegration time of the tablets when the starches were incorporated intra-granularly, which suggested particle-particle bond interruption and destruction of hydrogen bonds as mechanism of disintegration. Tablets containing 10 %w/w succinylated red lima bean starch incorporated intra-granularly had the highest disintegration efficiency ratio, DER, indicating a great balance between mechanical and disintegration properties. Modified red lima bean starches incorporated intra-granularly into paracetamol tablets led to faster disintegration and could efficiently substitute corn starch as disintegrant |
| Disciplinas: | Química |
| Palabras clave: | Química farmacéutica, Tabletas, Paracetamol, Excipientes extragranulares, Desintegración, Almidón modificado, Succinilación, Frijol lima rojo, Phaseolus lunatus, Fabaceae |
| Keyword: | Medicinal chemistry, Tablets, Paracetamol, Extragranular excipients, Disintegration, Modified starch, Succinylation, Red lima bean, Phaseolus lunatus, Fabaceae |
| Texte intégral: | Texto completo (Ver HTML) Texto completo (Ver PDF) |
