| Revue: | Brazilian Journal of Pharmaceutical Sciences |
| Base de datos: | PERIÓDICA |
| Número de sistema: | 000452159 |
| ISSN: | 1984-8250 |
| Autores: | Zhang, Ying1 Pi, Jiaxin1 Li, Wen1 Zhang, Ludan1 Ma, Xutong1 Kebebe, Dereje1 Qi, Dongli1 Li, Nan1 Guo, Pan1 Liu, Zhidong1 |
| Instituciones: | 1Tianjin University of Traditional Chinese Medicine, Tianjin State Key Laboratory of Modern Chinese Medicine,, Tianjin. China |
| Año: | 2022 |
| Volumen: | 58 |
| País: | Brasil |
| Idioma: | Inglés |
| Tipo de documento: | Artículo |
| Enfoque: | Experimental, aplicado |
| Resumen en inglés | Tongluo-Qutong rubber plaster (TQRP), a typical Chinese patent medicine that contains 13 different herbal remedies, is widely used in clinical practice for the treatment of cervical spondylosis and osteoarthritis. However, due to a lack of in vitro transdermal studies, the active ingredients of TQRP have not been fully elucidated. This presents a huge obstacle for quality evaluation, pharmacokinetic studies and clinical safety assessment of TQRP. In this work, a UPLC/UV/MS/MS method was established and validated to evaluate five analytes in TQRP. The validation demonstrated linearity (r > 0.99), specificity (no co-eluting peaks at the retention times of the analytes), and precision (RSD < 15%) within acceptable parameters. A skin permeation study was performed to determine the concentrations of drugs delivered to the dermis. The 24-hour cumulative permeation of ferulic acid, aleo-emodin, emodin and piperine were 303.68, 709.31, 671.06 and 25561.01 ng/cm2, respectively. According to the fitting data of the TQRP active components, skin permeation was mainly due to a combination of passive diffusion and drug release after matrix erosion |
| Disciplinas: | Química |
| Palabras clave: | Química farmacéutica, Productos naturales, Aplicación tópica, Permeación cutánea, Piperina |
| Keyword: | Medicinal chemistry, Natural products, Topic administration, Skin permeation, Piperine |
| Texte intégral: | Texto completo (Ver HTML) Texto completo (Ver PDF) |
