Revue: | Brazilian Journal of Pharmaceutical Sciences |
Base de datos: | PERIÓDICA |
Número de sistema: | 000451844 |
ISSN: | 1984-8250 |
Autores: | Scarim, Cauê Benito1 Andrade, Cleverton Roberto de2 Falcone, Rossana1 Ambrozini, Letícia Moreno1 Senhorelli, Vitor Izidoro1 Rosa, João Aristeu da1 Chin, Chung Man1 |
Instituciones: | 1Universidade Estadual Paulista "Julio de Mesquita Filho", Faculdade de Ciencias Farmaceuticas, Araraquara, Sao Paulo. Brasil 2Universidade Estadual Paulista "Julio de Mesquita Filho", Faculdade de Odontologia, Araraquara, Sao Paulo. Brasil |
Año: | 2022 |
Volumen: | 58 |
País: | Brasil |
Idioma: | Inglés |
Tipo de documento: | Artículo |
Enfoque: | Experimental, aplicado |
Resumen en inglés | The chemical hydroxymethylation of the antimicrobial nitrofurazone leads to the prodrug NFOH, also increases the anti-T. cruzi activities (in vitro and in vivo), as well as showed non-genotoxic (Ames and micronucleus assays). In the present study, we assessed the anti-T. cruzi effect of the NFOH In vivo - in acute Swiss and C57Bl/6 experimental Chagas models. The treatment started at 5 days post-infection during 20 consecutive days (orally, once day, 150mg/kg), and the parasitaemia as well as histopathology analysis were performed. In both experimental murine models, NFOH was able to reduce parasitemia blood avoiding parasitic reactivation, during immunosuppression period (dexamethasone 5mg/kg, 14 days), in 100% of the mice, and decrease tissue parasite nests, demonstrating absence of amastigote forms in all organs (100%) analyzed, data similar to benznidazole (BZN). Therefore, the results shown here pointing to the NFOH as promising compound for further preclinical studies, being a high potential drug to effective and safe chemotherapy to Chagas disease |
Disciplinas: | Medicina |
Palabras clave: | Parasitología, Farmacología, Enfermedad de Chagas, Trypanosoma cruzi, Hidroximetilnitrofurazona, Benzonidazol |
Keyword: | Parasitology, Pharmacology, Chagas disease, Trypanosoma cruzi, Hydroxymethylnitrofurazone, Benznidazole |
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