| Revue: | Brazilian Journal of Pharmaceutical Sciences |
| Base de datos: | PERIÓDICA |
| Número de sistema: | 000451899 |
| ISSN: | 1984-8250 |
| Autores: | Rampelotto, Roberta Filipini1 Coelho, Silvana Silveira1 Franco, Laísa Nunes1 Mota, Augusto Dias da1 Calegari, Luciano Fernandes1 Jacobi, Luciane Flores3 Hörner, Rosmari1 |
| Instituciones: | 1Universidade Federal de Santa Maria, Centro de Ciencias da Saude, Santa Maria, Rio Grande do Sul. Brasil 2Universidade Federal de Santa Maria, Hospital Universitario de Santa Maria, Santa Maria, Rio Grande do Sul. Brasil 3Universidade Federal de Santa Maria, Departamento de Estatistica, Santa Maria, Rio Grande do Sul. Brasil |
| Año: | 2022 |
| Volumen: | 58 |
| País: | Brasil |
| Idioma: | Inglés |
| Tipo de documento: | Artículo |
| Enfoque: | Aplicado, descriptivo |
| Resumen en inglés | Neonatal sepsis continues to be a major cause of morbidity and mortality worldwide. Coagulase-negative staphylococci (CoNS), commonly found on the skin, being the main agents isolated. The aim of this study was to evaluate CoNS isolated from blood cultures of newborn (NB) infants. The study took place between 2014 and 2016/2017 in a tertiary hospital in southern Brazil. Using the VITEK 2 system (bioMérieux, Marcy l'Etoile, France), the microorganisms were identified and had their sensitivity profiles determined. The minimum inhibitory concentrations of linezolid, tigecycline, and vancomycin were also determined. The clinical parameters and mortality rates of NBs were evaluated. From January to December 2014, 176 CoNS isolates were obtained from 131 patients and from June 2016 to July 2017, 120 CoNS isolates were obtained from 79 patients. Staphylococcus epidermidis was most prevalent in both periods. Resistance rates increased between 2014 and 2016/2017, especially against ciprofloxacin (52.27% and 73.11%, p = 0.0004), erythromycin (51.40% and 68.07%, p = 0.0054), gentamicin (50.59% and 67.23%, p = 0.0052), and penicillin (71.3% and 99.17%, p = 0.0001), respectively. With 100% susceptibility to linezolid, tigecycline, and vancomycin in both periods and methodologies tested. In 2014, 53.44% of the NBs received antibiotic therapy, and of these, 77.14% used a catheter; in 2016/2017, these were 78.48% and 95.16%, respectively. Regarding laboratory tests, a hemogram was ineffective, since patients with sepsis presented normal reference values. In 2014 and 2016/17, 15.71% and 17.74% of the NBs died, respectively. S. epidermidis was the predominant microorganism, related to catheter use in most cases. The resistance rates have increased over time, demonstrating the importance of adopting control and prevention measures in this hospital. CoNS are responsible for a significant neonatal sepsis mortality rate in infants |
| Disciplinas: | Medicina |
| Palabras clave: | Pediatría, Microbiología, Recién nacidos, Pruebas de sensibilidad microbiana, Hemocultivo, Sepsis, Mortalidad, Staphylococcus epidermidis |
| Keyword: | Pediatrics, Microbiology, Newborn, Microbial sensitivity tests, Blood culture, Sepsis, Mortality, Staphylococcus epidermidis |
| Texte intégral: | Texto completo (Ver HTML) Texto completo (Ver PDF) |
