| Revue: | Brazilian Journal of Pharmaceutical Sciences |
| Base de datos: | PERIÓDICA |
| Número de sistema: | 000452132 |
| ISSN: | 1984-8250 |
| Autores: | Vishwakarma, Vishal Kumar1 Upadhyay, Prabhat Kumar2 Gupta, Jeetendra Kumar2 Srivasata, Ritesh Kumar3 Ansari, Tarique Mahmood4 |
| Instituciones: | 1Rajarshi Rananjay Sinh College of Pharmacy, Department of Pharmacology, Amethi, Uttar Pradesh. India 2GLA University, Institute of Pharmaceutical Research, Mathura, Uttar Pradesh. India 3Kamla Nehru Institute of Management and Technology, Faculty of Pharmacy, Sultanpur, Uttar Pradesh. India 4Integral University, Faculty of Pharmacy, Lucknow, Uttar Pradesh. India |
| Año: | 2022 |
| Volumen: | 58 |
| País: | Brasil |
| Idioma: | Inglés |
| Tipo de documento: | Artículo |
| Enfoque: | Experimental, aplicado |
| Resumen en inglés | Ischemic postconditioning (IPTC) brings cardioprotection endogenously, Atrial natriuretic peptide (ANP) produces the same effect. It happens due to down expression of endothelial nitric oxide synthase (eNOS). Thus, experimental protocol associating IPTC has been formulated to find the role of ANP in the cardioprotection of heart in OVX rats. For this experiment, heart was isolated from OVX rat and held tightly on Langendorff’s apparatus in a manner that ischemia of 30 min and reperfusion of 120 min were also given. Simultaneously, IPTC with four cycles of 5 min ischemia and 5 min reperfusion of each was applied. Parameters like size of myocardial infarct, levels of lactate dehydrogenase (LDH) and release of creatine kinase- MB (CK-MB) in coronary effluent were noted after each stage of experiment for ensuring the extent of myocardial injury. Some significant changes were also seen in the histopathology of cardiovascular tissues. The cardio-protection has been made by four cycles of IPTC. It was confirmed by decline in the size of myocardial infarct. It diminishes the release of LDH and CK-MB in heart of OVX rat. Thus, IPTC induces cardio-protection in the isolated heart from OVX rat. Perfusion of ANP associating with IPTC favors the cardioprotection which is further confirmed by rise in the NO release and heart rate. The level of myocardial damage changes using IPTC, IPTC+OVX, IPTC+OVX+ANP, IPTC+ OVX+ANP+L-NAME and other groups were observed significantly and were found to be less than those in I/R control group. Thus, it is recommended that ANP involving IPTC restores attenuated cardio-protection in OVX rat heart. Therefore, Post-conditioning is useful in various clinical aspects |
| Disciplinas: | Medicina |
| Palabras clave: | Sistema cardiovascular, Farmacología, Medicina experimental, Isquemia, Cardioprotección, Péptido atrial natriurético, Oxido nítrico, Glibenclamida |
| Keyword: | Cardiovascular system, Pharmacology, Experimental medicine, Ischemia, Cardioprotection, Atrial natriuretic peptide, Nitric oxide, Glibenclamide |
| Texte intégral: | Texto completo (Ver HTML) Texto completo (Ver PDF) |
