| Revue: | Brazilian Journal of Pharmaceutical Sciences |
| Base de datos: | PERIÓDICA |
| Número de sistema: | 000451139 |
| ISSN: | 1984-8250 |
| Autores: | Upadhyay, Jyoti1 Rana, Mahendra1 Bisht, Satpal Singh2 Rana, Amita1 Durgapal, Sumit1 Juyal, Vijay1 |
| Instituciones: | 1Kumaun University, Department of Pharmaceutical Sciences, Bhimtal, Uttarakhand. India 2Kumaun University, Department of Zoology, Nainital, Uttarakhand. India |
| Año: | 2019 |
| Volumen: | 55 |
| País: | Brasil |
| Idioma: | Inglés |
| Tipo de documento: | Artículo |
| Enfoque: | Aplicado, descriptivo |
| Resumen en inglés | Experiments were conducted to investigate the effects on health of pregnant female rats exposed to pesticides glyphosate and carbendazim. Glyphosate is used as herbicide and carbendazim as a fungicide; all are commercially available readily for various agricultural and domestic purposes. The hypothesis tested in this investigation is that pesticide exposure during pregnancy causes changes in biomarker responses like serum glucose level, total protein, total cholesterol, triglycerides, SGOT, SGPT, and billirubin level. Significant changes were observed in all above biomarker responses, when compared with the reference. Histopathology of skin and kidney of rat neonates showed marked damage. Degenerative changes and vacuolization with eroded capsule were observed in kidney sample and thinning of epidermis in skin sample was seen in pesticides exposed neonates of rats. The serum biochemistry and histopathological findings are valuable markers for observing the changes caused by pesticide exposure |
| Disciplinas: | Biología, Química |
| Palabras clave: | Toxicología, Plaguicidas, Herbicidas, Análisis toxicológico, Glifosato, Carbendazim, Biomarcadores, Ratas |
| Keyword: | Toxicology, Pesticides, Herbicides, Toxicological analysis, Glyphosate, Carbendazim, Biomarkers, Rats |
| Texte intégral: | Texto completo (Ver HTML) Texto completo (Ver PDF) |
