| Revue: | Brazilian Journal of Pharmaceutical Sciences |
| Base de datos: | PERIÓDICA |
| Número de sistema: | 000452225 |
| ISSN: | 1984-8250 |
| Autores: | Farias, Cid Pinheiro1 Victoria, Paula Pólvora2 Xavier, Janaína2 Sekine, Fernanda Gelati2 Ribeiro, Eduardo Silveira3 Cognato, Giana de Paula2 Carvalho, Hudson Wander1 |
| Instituciones: | 1Universidade Federal de Pelotas, Faculdade de Medicina, Psicologia e Terapia Ocupacional, Pelotas, Rio Grande do Sul. Brasil 2Universidade Federal de Pelotas, Centro de Ciencias Quimicas, Farmaceuticas e de Alimentos, Pelotas, Rio Grande do Sul. Brasil 3Universidade Federal de Pelotas, Programa de Pos-Graduacao em Biotecnologia, Pelotas, Rio Grande do Sul. Brasil |
| Año: | 2022 |
| Volumen: | 58 |
| País: | Brasil |
| Idioma: | Inglés |
| Tipo de documento: | Artículo |
| Enfoque: | Experimental, aplicado |
| Resumen en inglés | Ayahuasca (AYA) is a psychedelic beverage with therapeutic potential for many mood and anxiety disorders. Although there are some preclinical studies, no published reports have tested the behavioral effects of AYA gavage in animal models. This investigation aimed to characterize the behavior of Wistar rats after acute ingestion of AYA for 40 min in the open field test (OFT). The sample consisted of three experimental groups treated with different dosages of AYA (125, 250, or 500 mg kg-1) and a control group. Each group consisted of 10 participants. After gavage, the number of crossings of the OFT grid lines, latency to enter the central area of the device, grooming frequency, and time spent in the central perimeter of the device were immediately evaluated. Analyses were based on one-way ANOVA and a linear-regression mixture model for longitudinal data. AYA intake did not interfere with habituation. The 500 mg kg-1 group showed a decrease in the time spent in the center of the device and in the number of crossings compared to the control group in the last 10 min. These results suggest that gavage with AYA did not interfere with the results, and the behavioral effects were perceived only between 30 and 40 min after gavage. Taken together, the results indicate that three aspects should be considered in OFT studies of AYA acute effects: the moment when the observation starts, the observation period, and the AYA dosage |
| Disciplinas: | Biología |
| Palabras clave: | Toxicología, Ayahuasca, Pruebas conductuales, Ratas |
| Keyword: | Toxicology, Ayahuasca, Behavioral tests, Rats |
| Texte intégral: | Texto completo (Ver HTML) Texto completo (Ver PDF) |
