Assessing compatibility of excipients selected for a sustained release formulation of bilberry leaf extract
Título del documento: Assessing compatibility of excipients selected for a sustained release formulation of bilberry leaf extract
Revue: Brazilian Journal of Pharmaceutical Sciences
Base de datos: PERIÓDICA
Número de sistema: 000451944
ISSN: 1984-8250
Autores: 1
2
1
3
1
Instituciones: 1National University of Pharmacy, Department of Industrial Technology of Drugs, Kharkiv. Ucrania
2Institute for Scintillation Materials of NAS of Ukraine, Nanostructured Materials Department, Kharkiv. Ucrania
3Kharkiv National Automobile and Highway University, Department of Automation and Computer-Aided Technologies, Kharkiv. Ucrania
Año:
Volumen: 58
País: Brasil
Idioma: Inglés
Tipo de documento: Artículo
Enfoque: Experimental, aplicado
Resumen en inglés The study is aimed to assess the compatibility of bilberry leaf powder extract (BLPE) with six excipients selected for sustained-release (SR) tablet formulation. The BLPE was obtained with the addition of L-arginine and Myo-inositol as the carriers. Thermogravimetric (TG-DTG) analysis and Fourier-transform infrared spectroscopy (FTIR), supported by Pearson correlation analysis, were applied to detect possible interactions in the binary mixtures (1:1) of the BLPE with each excipient. The TG-DTG showed some deviations in the thermal behavior of the BLPE / excipient mixtures. However, only the thermal behavior of magnesium stearate in the mixture significantly differed from individual samples, which suggested chemical interaction for this excipient. The FTIR analysis confirmed that the BLPE is compatible with Eudragit L100, Methocel K4M, Methocel K100LV, Avicel PH-101, and Plasdone S-630. Whereas it undergoes solid-state chemical interaction in the binary mixture with magnesium stearate. According to the FTIR-spectra, it is suggested that this interaction results in the formation of stearic acid and alkalization of the medium. These findings evidence for the possibility of using TG-DTG analysis as an independent thermal technique for compatibility studies and also confirm the earlier reported interaction of basic lubricants, e.g., stearic salts, with active ingredients containing amino groups
Disciplinas: Química
Palabras clave: Química farmacéutica,
Arándano,
Extractos vegetales,
Excipientes,
Liberación sostenida,
Análisis termogravimétrico,
Espectroscopía de infrarrojo por transformada de Fourier,
Vaccinium myrtillus,
Ericaceae
Keyword: Medicinal chemistry,
Bilberry,
Plant extracts,
Excipients,
Sustained release,
Thermogravimetric analysis,
Fourier transform infrared spectroscopy,
Vaccinium myrtillus,
Ericaceae
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