| Revue: | Brazilian Journal of Pharmaceutical Sciences |
| Base de datos: | PERIÓDICA |
| Número de sistema: | 000450916 |
| ISSN: | 1984-8250 |
| Autores: | Asif, Muhammad1 Saleem, Mohammad2 Yousaf, Sobia1 Saadullah, Malik1 Zafar, Memoona1 Khan, Rizwan Ullah3 Yuchi, Alamgeer4 |
| Instituciones: | 1Government College University, Faculty of Pharmaceutical Sciences, Faisalabad, Punjab. Pakistán 2University of the Punjab, University College of Pharmacy, Lahore, Punjab. Pakistán 3College of Medicine and Dentistry, Fatima Memorial Hospital, Lahore, Punjab. Pakistán 4University of Sargodha, College of Pharmacy, Sargodha, Punjab. Pakistán |
| Año: | 2019 |
| Volumen: | 55 |
| País: | Brasil |
| Idioma: | Inglés |
| Tipo de documento: | Artículo |
| Enfoque: | Experimental, aplicado |
| Resumen en inglés | The current study evaluated antidiabetic and antihyperlipidemic activities of aqueous extract of Sigesbeckia orientalis L. (St. Paul’s Wort) (AESO) in an alloxan-induced diabetic rat model. Following OECD guidelines safe doses of AESO were assessed in rats for the main study. Serum/bood glucose, α-amylase, and lipids levels and histopathological evaluations were conducted to assess antidiabetic and associated antihyperlipidemic efficacies of AESO. AESO was found to be safe up to the dose of 2000 mg/kg. Significant (p < 0.05) reduction in glucose and lipids (total cholesterol, triglycerides, low-density lipoproteins) levels was observed in AESO treatment groups. Serum α-amylase, high-density lipoproteins, and total body weight was increased significantly (p < 0.05) in diabetic rats treated with AESO. Histopathological data showed improvement in hepatocyte and pancreatic β-cells islets architecture. HPLC analysis identified quercetin, gallic acid, vanillic acid, p-coumaric acid, m-coumaric acid and cinnamic acid in AESO which are suggested to be responsible for observed antihyperglycemic and antihyperlipidemic attributes. Further studies to standardise the extract and evaluation of safety profile in long-term toxicity studies are recommended for safe and effective antidiabetic nutraceuticals development |
| Disciplinas: | Medicina, Química |
| Palabras clave: | Endocrinología, Farmacología, Fitoquímica, Diabetes, Actividad antihiperglicémica, Actividad antihiperlipidémica, Bioensayos, Extracto acuoso, Sigesbeckia orientalis, Asteraceae |
| Keyword: | Endocrinology, Pharmacology, Phytochemistry, Diabetes, Antihyperglycemic activity, Antihyperlipidemic activity, Bioassays, Aqueous extracts, Sigesbeckia orientalis, Asteraceae |
| Texte intégral: | Texto completo (Ver HTML) Texto completo (Ver PDF) |
