| Revue: | Brazilian Journal of Pharmaceutical Sciences |
| Base de datos: | PERIÓDICA |
| Número de sistema: | 000450914 |
| ISSN: | 1984-8250 |
| Autores: | Mahmoudian sani, Mohammad-Reza1 Sheikhshabani, SomayehHashemi2 Mirfakhar, Farzaneh Sadat3 Asgharzade, Samira2 |
| Instituciones: | 1Ahvaz Jundishapur University of Medical Sciences, Health Research Institute, Ahvaz. Irán 2Shahrekord University of Medical Sciences, Basic Health Sciences Institute, Shahrekord. Irán 3Universidade NOVA de Lisboa, Faculdade de Ciencias Medicas, Lisboa. Portugal |
| Año: | 2019 |
| Volumen: | 55 |
| País: | Brasil |
| Idioma: | Inglés |
| Tipo de documento: | Artículo |
| Enfoque: | Analítico, descriptivo |
| Resumen en inglés | Hearing loss induced by chemotherapy and acoustic trauma is mainly associated with two factors, free radical formation and apoptosis pathway activation. Despite numerous efforts on reducing the effects of these factors, no definite strategy is still determined to interfere with and control these processes. In recent studies, various protective agents, including antioxidants have been used on animal models, to inhibit the formation of free radicals thus improving hearing loss.In this review article we will discuss the role of traditional herbal medicine in treatment of noise/drug induced hearing loss, focusing on medicinal plants’ active substances,as well as their mechanisms of action in reducing or preventing the formation of free radicals thus increasing the rate of survival of cochlea cells. Data have been gathered since year 2000, from scientific publications including the following keywords: deafness, drug toxicity, acute trauma, medicinal herbs and oxidative stress. The study includes all herbs and medicinal plants that have been experimentally used in studies on animal models and clinical trials. The results from these studies indicate the effectiveness of most of these herbs and their active substances through their antioxidative properties. Medicinal plants reported in this review can thus be considered as effective remedies intreating noise/drug induced hearing loss,yet further studies need to be done |
| Disciplinas: | Medicina, Química |
| Palabras clave: | Otorrinolaringología, Fitoquímica, Química farmacéutica, Pérdida auditiva, Plantas medicinales, Trauma acústico, Ototoxicidad, Antioxidantes |
| Keyword: | Otolaryngology, Phytochemistry, Medicinal chemistry, Hearing loss, Medicinal plants, Ototoxicity, Acoustic trauma, Antioxidants |
| Texte intégral: | Texto completo (Ver HTML) Texto completo (Ver PDF) |
