| Revue: | Brazilian archives of biology and technology |
| Base de datos: | PERIÓDICA |
| Número de sistema: | 000392554 |
| ISSN: | 1516-8913 |
| Autores: | Rodrigues, Patrik Oening1 Becker, Ana Paula2 Dellagnelo, Viviane Aparecida2 Benetti, Cibele Nabhan1 Pereira, Eduardo Manoel2 Wagner, Theodoro Marcel2 Silva, Marcos Antonio Segatto3 |
| Instituciones: | 1Universidade Federal de Mato Grosso do Sul, Laboratorio de Tecnologia Farmaceutica, Campo Grande, Mato Grosso do Sul. Brasil 2Universidade da Regiao de Joinville, Departamento de Farmacia, Joinville, Santa Catarina. Brasil 3Universidade Federal de Santa Catarina, Departamento de Ciencias Farmaceuticas, Florianopolis, Santa Catarina. Brasil |
| Año: | 2014 |
| Periodo: | Nov-Dic |
| Volumen: | 57 |
| Número: | 6 |
| Paginación: | 887-894 |
| País: | Brasil |
| Idioma: | Inglés |
| Tipo de documento: | Nota breve o noticia |
| Enfoque: | Analítico, descriptivo |
| Resumen en inglés | The aim of this study was to evaluate the in vivo activity of the anti-inflammatory and analgesic effects of a suspension of the complex composed of dexamethasone acetate (DMA) with β -cyclodextrin in comparison to a suspension of the pure DMA. Solid complexes prepared by different methods were evaluated in pharmacodynamics and pharmacokinetics studies. The pharmacodynamic effect was investigated although the capacity of the inhibited the inflammation. Models of abdominal constriction, carrageenan-induced paw oedema and formalin induced licking were used. The study of the pharmacodynamic comparison of free DMA and products of β -CD:DMA demonstrated no significant difference in the majority of the tests performed. Plasma concentrations of DMA and DMA: β -CD were assayed by HPLC. A significant (p > 0.05) decrease in the relative bioavailability was obtained with the suspension containing the DMA: β -CD complex as measured by DMA plasma levels. The area under the curve (AUC) of the suspension of DMA was higher than that obtained with the suspension of the complexes. The pharmacokinetic evaluation of dexamethasone carried out on mice in the present study showed that complexed DMA with β -cyclodextrin modifieds some parameters related to the phases of absorption and elimination of this drug |
| Disciplinas: | Química, Medicina |
| Palabras clave: | Química farmacéutica, Farmacología, Solubilidad, Acetato de dexametasona, Beta-ciclodextrina, Biodisponibilidad, Actividad antiinflamatoria |
| Keyword: | Chemistry, Medicine, Medicinal chemistry, Pharmacology, Solubility, Dexamethasone acetate, Beta-cyclodextrin, Bioavailability, Anti-inflammatory activity |
| Texte intégral: | Texto completo (Ver PDF) |
