| Revue: | Brazilian archives of biology and technology |
| Base de datos: | PERIÓDICA |
| Número de sistema: | 000374041 |
| ISSN: | 1516-8913 |
| Autores: | Macedo, Ludmila Branco1 Lobato, Zelia Ines Portela2 Fialho, Sílvia Ligorio3 Viott, Aline de Marco2 Guedes, Roberto Maurício Carvalho2 Silva-Cunha, Armando1 |
| Instituciones: | 1Universidade Federal de Minas Gerais, Faculdade de Farmacia, Belo Horizonte, Minas Gerais. Brasil 2Universidade Federal de Minas Gerais, Escola de Veterinaria, Belo Horizonte, Minas Gerais. Brasil 3Fundacao Ezequiel Dias, Divisao de Desenvolvimento Farmacotecnico e Biotecnologico, Belo Horizonte, Minas Gerais. Brasil |
| Año: | 2013 |
| Periodo: | Nov-Dic |
| Volumen: | 56 |
| Número: | 6 |
| Paginación: | 932-941 |
| País: | Brasil |
| Idioma: | Inglés |
| Tipo de documento: | Artículo |
| Enfoque: | Experimental, aplicado |
| Resumen en inglés | This study investigated the adjuvant potential of W/O/W multiple emulsions and microemulsions, comparing them with traditional aluminum hydroxide and oil-in-water emulsion adjuvants against bluetongue vaccine (BTV). Local inflammatory reactions were assessed in rabbits by measuring the temperature of the animals and the skin thickness at the site of application. Antibodies titers were determined by serum-neutralization test. Histological analyses of lesions at the site of adjuvants application were done. Results showed that multiple emulsion and microemulsion maintained their stability even in the presence of complex components and presented adequate characteristics for subcutaneous administration. They were able to induce immune response against BTV, but it was smaller than the traditional adjuvants. Despite microemulsion adjuvant showed lower antibodies titre, it was easier to prepare more stable at 4°C and it was the only one that did not induce any local reaction |
| Disciplinas: | Medicina veterinaria y zootecnia, Química |
| Palabras clave: | Medicina veterinaria, Química farmacéutica, Inmunología, Lengua azul, Vacunas, Adyuvantes, Microemulsiones, Biocompatibilidad |
| Keyword: | Veterinary medicine and animal husbandry, Chemistry, Veterinary medicine, Medicinal chemistry, Immunology, Blue tongue, Vaccines, Adjuvants, Microemulsions, Biocompatibility |
| Texte intégral: | Texto completo (Ver HTML) |
