| Revue: | ARBS. Annual review of biomedical sciences |
| Base de datos: | PERIÓDICA |
| Número de sistema: | 000350439 |
| ISSN: | 1678-4618 |
| Autores: | Machado, Fernanda A1 Michelin, Marcia A1 Murta, Eddie F.C1 |
| Instituciones: | 1Universidade Federal do Triangulo Mineiro, Instituto de Pesquisa em Oncologia, Uberaba, Minas Gerais. Brasil |
| Año: | 2011 |
| Volumen: | 13 |
| Paginación: | 17-22 |
| País: | Brasil |
| Idioma: | Inglés |
| Tipo de documento: | Artículo |
| Enfoque: | Experimental, aplicado |
| Resumen en inglés | The evolution of cervical intraepithelial neoplasias (CINs) can lead to the development of cervical carcinomas and is closely tied to infection with human papillomavirus (HPV). Interferon (IFN)’s antitumor effects have a direct bearing on the proliferation or antigen composition of tumor cells, and act on specific tumor cells through immunomodulation. Moreover, some studies have indicated that type 1 IFN can have an antitumor effect by increasing levels of cytotoxic T cells, natural killer (NK) cells and dendritic cells (DCs). Immunotherapy with IFN has recently been used on cervical intraepithelial lesions and invasive cervical cancer with promising results. The objective of this mini-review is to discuss IFNs’ function, importance, and mechanism of action in the treatment of pre-malignant cervical neoplasias |
| Disciplinas: | Medicina |
| Palabras clave: | Oncología, Terapéutica, Neoplasia intraepitelial, Virus del papiloma humano, Inmunoterapia, Citocinas, Interferón |
| Keyword: | Medicine, Oncology, Therapeutics, Intraepithelial neoplasm, Human papillomavirus, Immunotherapy, Cytokines, Interferon |
| Texte intégral: | Texto completo (Ver PDF) |
