Nasopharyngeal carcinoma: an enigmatic tumor



Título del documento: Nasopharyngeal carcinoma: an enigmatic tumor
Revue: ARBS. Annual review of biomedical sciences
Base de datos: PERIÓDICA
Número de sistema: 000270169
ISSN: 1678-4618
Autores: 1

2
Instituciones: 1National University of Singapore, Yong Loo Lin School of Medicine, Singapur. Singapur
2Singapore General Hospital, Singapur. Singapur
Año:
Volumen: 10
Paginación: 27-35
País: Brasil
Idioma: Inglés
Tipo de documento: Artículo
Enfoque: Analítico
Resumen en inglés Nasopharyngeal cancer (NPC) is endemic in Southern China and South East Asia but is rare in the West. Men have a two to three times higher risk of developing the disease than women. NPC has been classified by the World Health Organization (WHO) into three categories based on the degree of differentiation, with WHO Type 3 being the most common histopathological type in endemic areas. The multifactorial etiologies of NPC include genetic predisposition, Epstein-Barr virus (EBV) infection, and environmental and dietary factors. Genetic linkage or association studies have demonstrated a correlation between the human Histocompatibility Leukocyte Antigen (HLA) haplotype and NPC susceptibility. Higher EBV antibody titers have been observed in most patients with undifferentiated NPC compared with normal controls. Consumption of salted fish containing volatile nitrosamines, especially during childhood, has been implicated as a possible factor contributing to NPC. The most common presenting symptom is enlarged cervical lymph nodes and patients may also have nasal, otological and neurological symptoms. Radiotherapy remains the main modality of treatment for this cancer
Disciplinas: Medicina
Palabras clave: Oncología,
Otorrinolaringología,
Terapéutica y rehabilitación,
Carcinoma,
Nariz,
Faringe,
Etiología,
Histopatología,
Epidemiología,
Genes
Keyword: Medicine,
Oncology,
Otolaryngology,
Therapeutics and rehabilitation,
Carcinoma,
Nose,
Pharynx,
Etiology,
Epidemiology,
Histopathology,
Genes
Texte intégral: Texto completo (Ver PDF)