| Revue: | Annals of hepatology |
| Base de datos: | PERIÓDICA |
| Número de sistema: | 000413426 |
| ISSN: | 1665-2681 |
| Autores: | Teschke, Rolf1 Schwarzenboeck, Alexander2 Frenzel, Christian2 Schulze, Johannes1 Eickhoff, Axel1 Wolff, Albrecht3 |
| Instituciones: | 1Goethe University, Medical Faculty, Frankfurt, Hessen. Alemania 2University Medical Center Hamburg-Eppendorf, Department of Medicine I, Hamburgo. Alemania 3Friedrich Schiller University of Jena, Division of Gastroenterology, Hepatology and Infectious Diseases, Jena, Thuringen. Alemania |
| Año: | 2016 |
| Periodo: | Ene-Feb |
| Volumen: | 15 |
| Número: | 1 |
| Paginación: | 91-118 |
| País: | México |
| Idioma: | Inglés |
| Tipo de documento: | Artículo |
| Enfoque: | Analítico, descriptivo |
| Resumen en inglés | In fall of 2013, the US Centers for Disease Control and Prevention (CDC) published a preliminary report on a cluster of liver disease cases that emerged in Hawaii in the summer 2013. This report claimed a temporal association as sufficient evidence that OxyELITE Pro (OEP), a dietary supplement (DS) mainly for weight loss, was the cause of this mysterious cluster. However, the presented data were inconsistent and required a thorough reanalysis. Material and methods. Material and methods. To further investigate the cause(s) of this cluster, we critically evaluated redacted raw clinical data of the cluster patients, as the CDC report received tremendous publicity in local and nationwide newspapers and television. This attention put regulators and physicians from the medical center in Honolulu that reported the cluster, under enormous pressure to succeed, risking biased evaluations and hasty conclusions. Results. Results. We Results. noted pervasive bias in the documentation, conclusions, and public statements, also poor quality of case management. Among the cases we reviewed, many causes unrelated to any DS were evident, including decompensated liver cirrhosis, acute liver failure by acetaminophen overdose, acute cholecystitis with gallstones, resolving acute hepatitis B, acute HSV and VZV hepatitis, hepatitis E suspected after consumption of wild hog meat, and hepatotoxicity by acetaminophen or ibuprofen. Causality assessments based on the updated CIOMS scale confirmed the lack of evidence for any DS including OEP as culprit for the cluster. Conclusions. Conclusions. Conclusions. Thus, the Hawaii liver disease cluster is now best explained by various liver diseases rather than any DS, including OEP |
| Disciplinas: | Medicina |
| Palabras clave: | Farmacología, Gastroenterología, Suplementos nutricionales, Efectos adversos, Hígado |
| Keyword: | Medicine, Gastroenterology, Pharmacology, Nutritional supplements, Adverse effects, Liver |
| Texte intégral: | Texto completo (Ver PDF) |
