The efficacy and safety of entecavir in patients with chronic hepatitis B- associated liver failure: a meta-analysis
Título del documento: The efficacy and safety of entecavir in patients with chronic hepatitis B- associated liver failure: a meta-analysis
Revue: Annals of hepatology
Base de datos: PERIÓDICA
Número de sistema: 000411345
ISSN: 1665-2681
Autores: 1
2
1
1
1
3
1
Instituciones: 1Shandong University, Jinan Infectious Disease Hospital, Jinan, Shandong. China
2Shandong University, School of Medicine, Jinan, Shandong. China
3Shandong University, Qianfoshan Hospital, Jinan, Shandong. China
Año:
Periodo: Mar-Abr
Volumen: 14
Número: 2
Paginación: 150-160
País: México
Idioma: Inglés
Tipo de documento: Artículo
Enfoque: Analítico, descriptivo
Resumen en inglés The effectiveness of nucleoside analogue (NA) treatment in patients with chronic hepatitis B (CHB) -associated liver failure is still controversial. Severe lactic acidosis has been reported during entecavir (ETV) treatment in patients with impaired liver function. Aim. To investigate the rescuing efficacy and safety of ETV in patients with CHB-associated liver failure. Material and methods. A literature search was carried out to collect articles dated up to December, 2013 on ETV therapy for patients with CHB-associated liver failure. Risk ratio (RR) and mean difference (MD) were used to measure the effects. Survival rate was used as the primary efficacy measure. The safety of ETV was assessed. Results. Six randomized controlled trials were selected. The overall analysis revealed ETV significantly improved survival at 4 weeks (RR = 1.35; 95% CI [1.16, 1.57]; p < 0.0001), 8 weeks (RR = 1.33; 95% CI [1.07, 1.64]; p = 0.009), 12 weeks (RR = 1.68; 95% CI [1.24, 2.28]; p = 0.0008). Pooled data also showed beneficial effects of antiviral therapy compared with control for HBV DNA negative change (RR = 5.35; 95% CI [2.06, 13.88]; p = 0.0006), TBIL and PTA improvement (TBIL: MD = -69.36; 95% CI [-134.37, -4.36]; p = 0.04. PTA: MD = 16.26; 95% CI [8.59, 23.94]; p < 0.0001). No adverse effect was identified in the examined studies. Conclusion. Our results showed that antiviral therapy with ETV improved the short-term survival of patients with CHB-associated liver failure. In addition, ETV was well tolerated during the treatment period. Further studies are still needed to strengthen these results
Disciplinas: Medicina
Palabras clave: Farmacología,
Gastroenterología,
Hepatitis B,
Hepatitis crónica,
Falla hepática,
Entecavir
Keyword: Medicine,
Gastroenterology,
Pharmacology,
Hepatitis B,
Chronic hepatitis,
Liver failure,
Entecavir
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