| Revue: | Annals of hepatology |
| Base de datos: | PERIÓDICA |
| Número de sistema: | 000406040 |
| ISSN: | 1665-2681 |
| Autores: | Castells, Lluís1 Llaneras, Jordi1 Campos Varela, Isabel2 Bilbao, Itxarone1 Crespo, Manel1 Len, Oscar1 Rodríguez Frías, Francisco3 Charco, Ramon1 Salcedo, Teresa1 Esteban, Juan Ignacio1 Esteban Mur, Rafael1 |
| Instituciones: | 1Universidad Autónoma de Barcelona, Hospital Universitario Vall d'Hebron, Barcelona. España 2Universidad de Santiago de Compostela, Santiago de Compostela, La Coruña. España 3Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas, Instituto de Salud Carlos III, Madrid. España |
| Año: | 2017 |
| Periodo: | Ene-Feb |
| Volumen: | 16 |
| Número: | 1 |
| Paginación: | 86-93 |
| País: | México |
| Idioma: | Inglés |
| Tipo de documento: | Artículo |
| Enfoque: | Experimental, caso clínico |
| Resumen en inglés | Pegylated interferon (Peg-INF) and ribavirin (RBV) based therapy is suboptimal and poorly tolerated. We evaluated the safety, tolerability and efficacy of a 24-week course of sofosbuvir plus daclatasvir without ribavirin for the treatment of hepatitis C virus (HCV) recurrence after liver transplantation (LT) in both HCV-monoinfected and human immunodeficiency virus (HIV)-HCV coinfected patients. Material and methods. We retrospectively evaluated 22 consecutive adult LT recipients (16 monoinfected and 6 coinfected with HIV) who received a 24-week course of sofosbuvir plus daclatasvir treatment under an international compassionate access program. Results. Most patients were male (86%), with a median age of 58 years (r:58-81y). Median time from LT to treatment onset was 70 months (r: 20-116 m). HCV genotype 1b was the most frequent (45%), 55% had not responded to previous treatment with Peg-INF and RBV and 14% to regiments including first generation protease inhibitors. Fifty-six percent of the patients had histologically proven cirrhosis and 6 had ascites at baseline. All patients completed the 24-week treatment course without significant side effects except for one episode of severe bradicardya, with only minor adjustments in immunosuppressive treatment in some cases. Viral suppression was very rapid with undetectable HCV-RNA in all patients at 12 weeks. All 22 patients achieved a sustained virological response 12 weeks after treatment completion. Conclusion. The combination of sofosbuvir plus daclatasvir without ribavirin is a safe and effective treatment of HCV recurrence after LT in both monoinfected and HIV-coinfected patients, including those with decompensated cirrhosis |
| Disciplinas: | Medicina |
| Palabras clave: | Gastroenterología, Microbiología, Terapéutica y rehabilitación, Antivirales, Interacción medicamentosa, Trasplantes, Hígado, Hepatitis C, VIH |
| Keyword: | Medicine, Gastroenterology, Microbiology, Therapeutics and rehabilitation, Antivirals, Drug interaction, Transplantation, Liver, Hepatitis C, HIV |
| Texte intégral: | Texto completo (Ver HTML) |
