| Revue: | Annals of hepatology |
| Base de datos: | PERIÓDICA |
| Número de sistema: | 000406023 |
| ISSN: | 1665-2681 |
| Autores: | Kubíckova, Kristyna1 Subhanova, Iva1 Koníckova, Renata1 Matousova, Linda1 Urbanek, Petr1 Parobkova, Hana2 Kupec, Martin1 Pudil, Jirí3 Vítek, Libor1 |
| Instituciones: | 1Charles University, First Faculty of Medicine, Praga. República Checa 2Military University Hospital, Department of Radiology, Praga. República Checa 3Charles University, 2nd Faculty of Medicine, Praga. República Checa |
| Año: | 2016 |
| Periodo: | Nov-Dic |
| Volumen: | 15 |
| Número: | 6 |
| Paginación: | 881-887 |
| País: | México |
| Idioma: | Inglés |
| Tipo de documento: | Artículo |
| Enfoque: | Analítico, descriptivo |
| Resumen en inglés | Hepatocellular carcinoma (HCC) is the most common primary malignant liver tumor. It is primarily caused by hepatic cirrhosis or chronic viral hepatitis. Hepatic carcinogenesis is associated with increased oxidative stress. Thus, the aim of our study was to assess expression of the genes involved in the homeostasis of oxidative stress in patients with HCC. Material Material and methods. and methods. The study was and methods. performed on 32 patients with primary HCC (verified by liver histology in 29 patients) and 27 control subjects (in 11 subjects, liver histology was available either with no or minimal changes in the liver tissue). Gene expressions of heme oxygenase 1 (HMOX1), biliverdin reductase A/B (BLVRA/B), NADPH oxidase 2 (NOX2) and p22phox were analyzed in the liver and peripheral blood leukocytes (PBL) in the subjects. Results. Results. Results. Compared to controls, almost a 3 times higher mRNA level of BLVRA was detected in livers of HCC patients (p = 0.002); while those of BLVRB as well as HMOX1 were unchanged (p > 0.05). In accord with these results in the liver tissue, BLVRA mRNA levels in PBL were also significantly increased in HCC patients (p = 0.012). mRNA levels of NOX2 and p22phox in the liver tissue, although higher in HCC patients, did not differ significantly compared to control subjects (p > 0.05). Nevertheless, NOX2 mRNA level in PBL was significantly higher in HCC patients (p = 0.003). Conclusions. Conclusions. Conclusions. BLVRA mRNA levels in the liver as well as in PBL are significantly higher in HCC patients most likely as a feedback mechanism to control increased oxidative stress associated with HCC progression |
| Disciplinas: | Medicina |
| Palabras clave: | Diagnóstico, Gastroenterología, Oncología, Carcinoma hepatocelular, Factores predictivos, Biliverdina reductasa, Cirrosis hepática, Estrés oxidativo |
| Keyword: | Medicine, Diagnosis, Gastroenterology, Oncology, Hepatocellular carcinoma, Predictive factors, Biliverdin reductase, Liver cirrhosis, Oxidative stress |
| Texte intégral: | Texto completo (Ver PDF) |
