Metastatic lymphoepithelioma-like hepatocellular carcinoma: a potential diagnostic pitfall and demonstration of Pd-l1 expression
Título del documento: Metastatic lymphoepithelioma-like hepatocellular carcinoma: a potential diagnostic pitfall and demonstration of Pd-l1 expression
Revue: Annals of hepatology
Base de datos: PERIÓDICA
Número de sistema: 000406068
ISSN: 1665-2681
Autores: 1
2
2
3
1
Instituciones: 1Icahn School of Medicine at Mount Sinai, Department of Pathology, Nueva York. Estados Unidos de América
2Lenox Hill Hospital, Department of Surgery, Houston, Texas. Estados Unidos de América
3Icahn School of Medicine at Mount Sinai, Department of Medicine, Nueva York. Estados Unidos de América
Año:
Periodo: Ene-Feb
Volumen: 16
Número: 1
Paginación: 157-159
País: México
Idioma: Inglés
Tipo de documento: Artículo
Enfoque: Caso clínico, analítico
Resumen en inglés Lymphoepithelioma-like hepatocellular carcinoma (LEL-HCC) is a rare primary hepatic neoplasm with female predominance and relatively good prognosis. We report a 73-year-old female with chronic hepatitis B who developed metastatic lesions 5 years after underwent resection for LEL-HCC. The metastatic lesions showed a spectrum of morphologic findings, which could be mistaken for other entities such as lymphoma, particularly in lesions with single-cell infiltrative pattern and abundant tumor-infiltrating lymphocytes. Immunohistochemical study to confirm the origin of the neoplastic cells is important to make the diagnosis. We also highlighted the clinicopathologic correlation and potential therapeutic implication of programmed death ligand-1 expression in LEL-HCC
Disciplinas: Medicina
Palabras clave: Diagnóstico,
Gastroenterología,
Oncología,
Linfoepitelioma,
Carcinoma hepatocelular,
Hepatitis B,
Hepatitis crónica,
Metástasis,
PD-1,
Histología
Keyword: Medicine,
Diagnosis,
Gastroenterology,
Oncology,
Lymphoepithelioma,
Hepatocellular carcinoma,
Hepatitis B,
Chronic hepatitis,
Metastasis,
PD-1,
Histology
Texte intégral: Texto completo (Ver HTML)