| Revue: | Annals of hepatology |
| Base de datos: | PERIÓDICA |
| Número de sistema: | 000413467 |
| ISSN: | 1665-2681 |
| Autores: | Rosa-Toledo, Olegario1 Almeida-Chuffa, Luiz G1 Martinez, Marcelo2 Felipe-Pinheiro, Patricia F1 Padovani, Carlos R1 Martinez, Francisco E1 |
| Instituciones: | 1Universidade Estadual Paulista "Julio de Mesquita Filho", Instituto de Biociencias, Botucatu, Sao Paulo. Brasil 2Universidade Federal de Sao Carlos, Departamento de Morfologia e Patologia, Sao Carlos, Sao Paulo. Brasil |
| Año: | 2015 |
| Periodo: | Nov-Dic |
| Volumen: | 14 |
| Número: | 6 |
| Paginación: | 910-918 |
| País: | México |
| Idioma: | Inglés |
| Tipo de documento: | Artículo |
| Enfoque: | Analítico, descriptivo |
| Resumen en inglés | We designed to test whether there is interaction of maternal separation (MS) on the ethanol-preferring rats liver structure. The UCh rat pups were separated daily from their mothers during the stress hyporesponsive period (SHRP), between four and 14 days-old, always at the same time for four hours in a cage containing eight subdivisions, one for each pup. Subsequently, rats that presented the highest (UChB) and the lowest (UChA) ethanol (EtOH) consumption were selected to the study. Both UChB and UChA rats received 10% (v/v) EtOH and distilled water ad libitum until the end of the experiment (120 days-old). The liver was collected to histological routine for morphometric and stereological analyses, and immunohistochemistry. Results. There was an interaction of MS and EtOH on the liver: increased liver mass, peritubular vessels, stellate cell numbers, steatosis and cell death, decreased necrosis, sinusoidal capillary diameters and cell proliferation. While there was a decrease in FSH, testosterone and 5α-di-hidrotestosterone, and increasing corticosterone and cholesterol. Conclusions. There is interaction of MS and EtOH on the liver structure, dependent on the amount of EtOH intake. Furthermore, the interaction of stress and drugs can increase or decrease their effects on the liver or indirectly via hypothalamic-pituitary-adrenal (HPA) and hypothalamic-pituitary-gonadal (HPG) axes |
| Disciplinas: | Medicina |
| Palabras clave: | Medicina experimental, Ratas, Separación materna, Consumo de alcohol, Estrés, Inmunohistoquímica, Hígado |
| Keyword: | Medicine, Experimental medicine, Rats, Maternal separation, Alcohol consumption, Stress, Immunohistochemistry, Liver |
| Texte intégral: | Texto completo (Ver PDF) |
