| Revue: | Annals of hepatology |
| Base de datos: | PERIÓDICA |
| Número de sistema: | 000390965 |
| ISSN: | 1665-2681 |
| Autores: | Szabo, Shelagh M1 Samp, Jennifer C2 Walker, David R2 Lane, Suzanne1 Cline, Stephanie K2 Gooch, Katherine L2 Jiménez Méndez, Ricardo3 Levy, Adrian R4 |
| Instituciones: | 1ICON Epidemiology, Vancouver, Columbia Británica. Canadá 2AbbVie Global Health Economics and Outcomes Research, Abbott Park, Illinois. Estados Unidos de América 3University of British Columbia, Vancouver, Columbia Británica. Canadá 4Dalhousie University, Department of Community Health and Epidemiology, Halifax, Nova Scotia. Canadá |
| Año: | 2015 |
| Periodo: | Sep-Oct |
| Volumen: | 14 |
| Número: | 5 |
| Paginación: | 618-630 |
| País: | México |
| Idioma: | Inglés |
| Tipo de documento: | Revisión bibliográfica |
| Enfoque: | Analítico |
| Resumen en inglés | Despite reports that mortality is increasing, overall case fatality due to hepatitis C virus (HCV) is thought to be low. Given the variability in published rates, we aimed to synthesize estimates of liver-specific case fatality and all-cause mortality in chronic HCV according to follow-up duration, sustained viral response (SVR) to treatment, and liver disease severity. A systematic review was conducted of studies published in English from 2003 to 2013, reporting liver-specific case fatality estimates from HCV-infected samples. Thirty-five eligible articles were identified; 26 also presented estimates of all-cause mortality. Among community-based samples, liver-specific case fatality ranged from 0.3% over 5.7 years to 9.2% over 8.2 years of follow-up; and of all-cause mortality, from 4.0% over 5.7 years, to 23.0% over 8.2 years of follow-up. Estimates were higher among clinic-based samples and those with more severe liver disease. Among treated patients achieving SVR, liver-specific case fatality was low: up to 1.4% over 11.5 years of follow-up among samples with any severity of liver disease. Estimates were higher among those without SVR: up to 14.0% over 10 years of followup among samples with any severity of liver disease, and higher still among samples with more severe liver disease. The proportion of deaths attributable to liver-specific causes ranged from 55 to 85% among those with severe liver disease. Published estimates of fatality are high among certain populations of chronic HCV patients, with liver-specific causes being an important contributor. Understanding current HCV mortality rates is important for quantifying the total burden of HCV disease |
| Disciplinas: | Medicina |
| Palabras clave: | Gastroenterología, Microbiología, Salud pública, Hepatitis C, Mortalidad, Revisiones sistemáticas |
| Keyword: | Medicine, Gastroenterology, Microbiology, Public health, Hepatitis C, Mortality, Systematic reviews |
| Texte intégral: | Texto completo (Ver PDF) |
