| Revue: | Annals of hepatology |
| Base de datos: | PERIÓDICA |
| Número de sistema: | 000411694 |
| ISSN: | 1665-2681 |
| Autores: | Bessone, Fernando1 Roma, Marcelo Gabriel2 |
| Instituciones: | 1Universidad del Rosario, Facultad de Ciencias Médicas, Rosario, Santa Fe. Argentina 2Universidad del Rosario, Facultad de Ciencias Bioquímicas y Farmacéuticas, Rosario, Santa Fe. Argentina |
| Año: | 2016 |
| Periodo: | May-Jun |
| Volumen: | 15 |
| Número: | 3 |
| Paginación: | 442-447 |
| País: | México |
| Idioma: | Inglés |
| Tipo de documento: | Artículo |
| Enfoque: | Caso clínico, analítico |
| Resumen en inglés | Ursodeoxycholic acid (UDCA) is the first choice medication for most cholestatic hepatopathies, due to its capability to counteract inflammation and bile-acid-induced liver damage, two common features in cholestasis. However, UDCA is usually contraindicated in obstructive cholestasis, due to the alleged risk of biliary integrity disruption due to its choleretic effect. We report on an 83-year-old man with an unsuspected malignant biliary obstruction who received moderate doses of UDCA (8-12 mg/kg/day) for 5 weeks, because the preliminary evidence suggested he had chemotherapy-induced cholestasis. Liver integrity was extensively protected by UDCA, as indicated by a marked decrease in serum liver enzymes, despite a steady increase in the levels of bilirubin and serum bile acids due to the obstructive process. In conclusion, this report shows, for the first time in humans, that moderate UDCA doses can reduce liver injury associated with complete biliary obstruction. This may contribute to a better understanding of the risk-benefit ratio of the use of UDCA in obstructive cholangiopathies |
| Disciplinas: | Medicina |
| Palabras clave: | Farmacología, Gastroenterología, Oncología, Acido ursodeoxicólico, Obstrucción biliar, Colestasis, Función hepática, Vías biliares |
| Keyword: | Medicine, Gastroenterology, Oncology, Pharmacology, Ursodeoxycholic acid, Biliary obstruction, Cholestasis, Liver function, Biliary tract |
| Texte intégral: | Texto completo (Ver PDF) |
