| Revue: | Annals of hepatology |
| Base de datos: | PERIÓDICA |
| Número de sistema: | 000413410 |
| ISSN: | 1665-2681 |
| Autores: | Unzueta, Alberto1 Valdez, Riccardo2 Chang, Yu-Hui H2 Desmarteau, Yvonne M2 Heilman, Raymond L2 Scott, Robert L2 Douglas, David D2 Rakela, Jorge2 |
| Instituciones: | 1University of Florida, Division of Gastroenterology, Hepatology and Nutrition, Gainesville, Florida. Estados Unidos de América 2Mayo Clinic, Scottsdale, Arizona. Estados Unidos de América |
| Año: | 2016 |
| Periodo: | Ene-Feb |
| Volumen: | 15 |
| Número: | 1 |
| Paginación: | 33-40 |
| País: | México |
| Idioma: | Inglés |
| Tipo de documento: | Artículo |
| Enfoque: | Analítico, descriptivo |
| Resumen en inglés | Acute Background. hepatitis E virus (HEV) infection in solid organ transplant recipients is rare, but can cause severe hepatic and extrahepatic complications. We sought to identify the pretransplant prevalence of HEV infection in heart and kidney candidates and any associated risk factors for infection. Material and methods. Material and methods. Stored froze Material and methods. n serum from patients undergoing evaluation for transplant was tested for HEV immunoglobulin G (IgG) antibodies and HEV RNA. All patients were seen at Mayo Clinic Hospital, Phoenix, Arizona, with 333 patients evaluated for heart (n = 132) or kidney (n = 201) transplant. HEV IgG antibodies (anti-HEV IgG) were measured by enzyme-linked immunosorbent assay, and HEV RNA by a noncommercial nucleic acid amplification assay. Results. The sults. prevalence of anti-HEV IgG was 11.4% (15/132) for heart transplant candidates and 8.5% (17/201) for kidney transplant candidates, with an overall seroprevalence of 9.6% (32/333). None of the patients tested positive for HEV RNA in the serum. On multivariable analysis, age older than 60 years was associated with HEV infection (adjusted odds ratio, 3.34; 95% CI, 1.54-7.24; P = 0.002). Conclusions. Conclusions. We Conclusions. conclude that there was no evidence of acute HEV infection in this pretransplant population and that older age seems to be associated with positive anti-HEV IgG |
| Disciplinas: | Medicina |
| Palabras clave: | Gastroenterología, Inmunología, Virus de la hepatitis E, Anticuerpos séricos, Prevalencia, ELISA, Epidemiología, Trasplante de corazón, Trasplante de riñón |
| Keyword: | Medicine, Gastroenterology, Immunology, Hepatitis E virus, Serum antibodies, Prevalence, ELISA, Epidemiology, Heart transplantation, Kidney transplantation |
| Texte intégral: | Texto completo (Ver PDF) |
