| Revue: | Annals of hepatology |
| Base de datos: | PERIÓDICA |
| Número de sistema: | 000415633 |
| ISSN: | 1665-2681 |
| Autores: | Rodríguez Medina, Beatriz1 Blanes, Marino2 Vinaixa, Carmen1 Aguilera, Victoria1 Rubín, Angel1 Prieto, Martín1 Berenguer, Marina1 |
| Instituciones: | 1Hospital La Fe, Unidad de Trasplante de Hígado y Hepatología, Valencia. España 2Hospital La Fe, Unidad de Enfermedades Infecciosas, Valencia. España |
| Año: | 2013 |
| Periodo: | Nov-Dic |
| Volumen: | 12 |
| Número: | 6 |
| Paginación: | 974-978 |
| País: | México |
| Idioma: | Inglés |
| Tipo de documento: | Artículo |
| Enfoque: | Analítico, descriptivo |
| Resumen en inglés | Haemophagocytic syndrome (HS) is a rare disease that is often fatal despite treatment. HS is characterized by fevers, lymphadenopathy, hepatosplenomegaly, cytopenias and hyperferritinaemia due to deregulated activation and proliferation of macrophages, leading to uncontrolled phagocytosis of platelets, erythrocytes, lymphocytes, and their hematopoietic precursors throughout the reticuloendothelial system. Mycobacterium tuberculosis-associated HS is a rare and underdiagnosed association with only 39 cases reported. We describe a case of HS associated with disseminated Mycobacterium tuberculosis in the setting of post-liver transplantation anti-hepatitis C therapy with pegylated interferon (pegIFN), ribavirin (RBV) and telaprevir (TVR). Despite the delay in the etiologic diagnosis, the patient was treated properly with corticosteroids, cyclosporine and tuberculostatic agents. It is unknown whether telaprevir, a drug that only recently has been started off-label in liver transplant recipients, may have contributed to the development of the HS. Unfortunately, as in many reported cases of HS, the outcome was unfavourable resulting in the death of the patient |
| Disciplinas: | Medicina |
| Palabras clave: | Cirugía, Gastroenterología, Trasplante de hígado, Complicaciones postoperatorias, Síndrome hemofagocítico, Tuberculosis, Telaprevir |
| Keyword: | Medicine, Gastroenterology, Surgery, Liver transplantation, Postoperative complications, Hemophagocytic syndrome, Tuberculosis, Telaprevir |
| Texte intégral: | Texto completo (Ver PDF) |
