| Revue: | Annals of hepatology |
| Base de datos: | PERIÓDICA |
| Número de sistema: | 000409079 |
| ISSN: | 1665-2681 |
| Autores: | Lau, Su Yin1 Woodman, Richard J3 Silva, Mauricio F2 Muller, Kate1 Libby, John2 Chen, John W2 Padbury, Robert2 Wigg, Alan J1 |
| Instituciones: | 1Flinders Medical Centre, Hepatology and Liver Transplant Medicine Unit, Adelaide, Australia Meridional. Australia 2Flinders Medical Centre, The South Australian Liver Transplant Unit, Adelaide, Australia Meridional. Australia 3Flinders University of South Australia, School of Medicine, Adelaide, Australia Meridional. Australia |
| Año: | 2016 |
| Volumen: | 15 |
| Número: | 2 |
| Paginación: | 207-214 |
| País: | México |
| Idioma: | Inglés |
| Tipo de documento: | Artículo |
| Enfoque: | Aplicado, descriptivo |
| Resumen en inglés | Concerns exist about outcomes of liver transplantation (LT) from low volume centres, especially for hepatitis C (HCV) patients. The aim of the study was to assess patient outcomes as well as their predictors post LT for HCV in a small volume Australian unit (< 25 LTs/year), comparing these with the average outcomes obtained from national and international transplant registries. Patients transplanted for HCV at the South Australian Liver Transplant Unit between 1992 and 2012 were studied. Outcomes assessed were patient and graft survival at 1,3, and 5 years. Factors independently associated with the outcomes were assessed using Cox regression model. Results. Results. 1, 3 Results. , and 5-year patient survival for HCV patients was 95.2, 82.9, and 78.2%, graft survival were 93.7, 80.1, and 75.5% respectively. The total follow-up time observed was 299.9 years amongst 61 patients in which there were 16 deaths. The expected number of deaths was 40.4 and the standardized mortality ratio 0.40 (95% CI = 0.24, 0.65). These results compared favourably to those obtained from the SRTR registry. Variables independently associated with lower patient survival: donor age (HR = 1.06, 95% CI 1.02 - 1.11; P = 0.003), and post LT cytomegalovirus (CMV) disease requiring treatment (HR = 4.03, 95% CI 1.48 - 10.92;P = 0.06). Conclusion. Conclusion. In Conclusion. conclusion, high rates of patient and graft survival for HCV liver transplantation can be obtained in a small volume unit. Young donor age and lack of CMV disease post-transplant were associated with better outcomes. Institutional factors may be influential determinants of outcomes |
| Disciplinas: | Medicina |
| Palabras clave: | Cirugía, Gastroenterología, Hepatitis C, Trasplante de hígado, Sobrevivencia |
| Keyword: | Medicine, Gastroenterology, Surgery, Hepatitis C, Liver transplantation, Survival |
| Texte intégral: | Texto completo (Ver PDF) |
