| Revue: | Annals of hepatology |
| Base de datos: | PERIÓDICA |
| Número de sistema: | 000391022 |
| ISSN: | 1665-2681 |
| Autores: | Martínez, Jorge1 Besa, Santiago1 Arab, Juan P1 Quintana, Juan C1 Regonesi, Carlos2 Huete, Alvaro1 Jarufe, Nicolás1 Guerra, Juan F1 Benítez, Carlos1 Arrese, Marco1 |
| Instituciones: | 1Pontificia Universidad Católica de Chile, Facultad de Medicina, Santiago de Chile. Chile 2Clínica Las Condes, Unidad de Oncología, Santiago de Chile. Chile |
| Año: | 2015 |
| Periodo: | Sep-Oct |
| Volumen: | 14 |
| Número: | 5 |
| Paginación: | 752-755 |
| País: | México |
| Idioma: | Inglés |
| Tipo de documento: | Artículo |
| Enfoque: | Caso clínico |
| Resumen en inglés | Gastrointestinal neuroendocrine tumors (NET) frequently present with unresectable hepatic metastases, which poses a barrier for curative treatment. Resection of the primary tumor and subsequent orthotopic liver transplantation (OLT) has been proposed as a treatment approach but available data in this regard is limited. We present a clinical case of an otherwise asymptomatic 44-yo man complaining of abdominal pain and dyspepsia that was diagnosed of a 10 cm duodenal tumor with multiple hepatic metastases. A CT-guided biopsy confirmed a NET. He underwent first a Whipple’s procedure, and then was listed for liver transplantation. During the waiting time a multimodal therapeutic approach was used including the use of radioactive 177lutetium-labeled somatostatin analogues, long-acting somastostatin analogues and antiangiogenic antibodies (bevacizumab) in order to keep neoplastic disease under control. Two years after Whipple’s procedure and given disease stability he underwent OLT with an uneventful postoperative evolution. Patient condition and graft function are optimal after a 4-year follow-up period with no evidence of recurrence. This case report underscores how a multimodal approach involving careful patient selection, resective surgery as well as use of somatostatin analogues and antiangiogenic biological therapy followed by liver transplantation can achieve excellent long-term results in this difficult patient population |
| Disciplinas: | Medicina |
| Palabras clave: | Cirugía, Gastroenterología, Oncología, Tumores neuroendócrinos, Hígado, Trasplantes, Metástasis |
| Keyword: | Medicine, Gastroenterology, Oncology, Surgery, Neuroendocrine tumors, Liver, Transplantation, Metastasis |
| Texte intégral: | Texto completo (Ver PDF) |
