| Revue: | Annals of hepatology |
| Base de datos: | PERIÓDICA |
| Número de sistema: | 000390987 |
| ISSN: | 1665-2681 |
| Autores: | Cardoso Saldaña, Guillermo C1 Medina Urrutia, Aída X1 Posadas Romero, Carlos1 Juárez Rojas, Juan G1 Jorge Galarza, Esteban1 Vargas Alarcón, Gilberto2 Posadas Sánchez, Rosalinda1 |
| Instituciones: | 1Instituto Nacional de Cardiología Ignacio Chávez, Departamento de Endocrinología, México, Distrito Federal. México 2Instituto Nacional de Cardiología Ignacio Chávez, Departamento de Biología Molecular, México, Distrito Federal. México |
| Año: | 2015 |
| Periodo: | Sep-Oct |
| Volumen: | 14 |
| Número: | 5 |
| Paginación: | 658-665 |
| País: | México |
| Idioma: | Inglés |
| Tipo de documento: | Estadística o encuesta |
| Enfoque: | Analítico |
| Resumen en inglés | Fatty liver (FL) and abdominal visceral fat (AVF) are strongly associated with systemic inflammation, however, it has not been defined if each one is independently involved, and if the insulin resistance is associated. To investigate if FL, AVF and insulin resistance are independently or additively associated with the high-sensitivity C-reactive protein (hs-CRP) in subjects without coronary artery disease we included 491 men and 553 women. Material and methods. All had anthropometric and plasma biochemical measurements, FL and AVF assessments by computed tomography. Results. The FL prevalence was 35.6% in men and 28.0% in women, p < 0.01. The prevalence of obesity, metabolic syndrome and homeostasis model assessment of insulin resistance (HOMA-IR) was significantly higher in FL compared to non FL subjects. FL and AVF accounted for 21 and 17%, respectively, to hs-CRP plasma levels. FL, AVF ≥ P75 and HOMA-IR ≥ P75 were independently and additively associated with plasma hs-CRP. The risk of hs-CRP ≥ 3 mg/L increased progressively in men from 1.36 (0.5-3.86) through 3.58 (1.32-9.7) in those with 1 or 3 factors respectively. In women from 2.25 (1.2-4.2) to 4.67 (2.3-9.4), respectively. In conclusion, both the FL and hs-CRP ≥ 3 mg/L occur in 1 of every 3 non CAD subjects. In men, FL and AVF ≥ P75 were associated with 3.6 times the risk of hs-CRP ≥ 3 mg/L, while in women, these factors were independently and additively associated with a 4.7 times higher risk of systemic inflammation |
| Disciplinas: | Medicina |
| Palabras clave: | Gastroenterología, Metabolismo y nutrición, Inmunología, Hígado graso, Resistencia a la insulina, Adiposidad, Respuesta inflamatoria sistémica, Obesidad visceral |
| Keyword: | Medicine, Gastroenterology, Metabolism and nutrition, Immunology, Fatty liver, Insulin resistance, Adiposity, Systemic inflammatory response, Visceral obesity |
| Texte intégral: | Texto completo (Ver PDF) |
