Epidemiologic trends in HBV infections at a reference centre in Turkey: an 11-year retrospective analysis



Título del documento: Epidemiologic trends in HBV infections at a reference centre in Turkey: an 11-year retrospective analysis
Revue: Annals of hepatology
Base de datos: PERIÓDICA
Número de sistema: 000419057
ISSN: 1665-2681
Autores: 1
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Instituciones: 1Hacettepe University, Faculty of Medicine, Ankara. Turquía
Año:
Periodo: Sep-Oct
Volumen: 11
Número: 5
Paginación: 672-678
País: México
Idioma: Inglés
Tipo de documento: Artículo
Enfoque: Analítico, descriptivo
Resumen en inglés To identify changes in hepatitis B epidemiology after the implementation of the nationwide vaccination program in Turkey, hepatitis B virus (HBV) and related tests performed over a period of 11 years (2000-2010) at a reference centre were retrospectively overviewed and statistically analysed for trends. Results. Assay results for Hepatitis B surface antigen (HBsAg) and e antigen (HBeAg), Anti-HBs, Anti-HBe, Anti-HBc immunoglobulins and HBV DNA as well as aspartate aminotransferase (AST), alanine aminotransferase (ALT), gama-glutamyl transpeptidase (GGT) and alkaline phosphatase (AP) levels, obtained via standardized commercial assays were included in the analysis. Overall, a stable anti-HBs incidence (43.6%) and male predominance in infected individuals were noted. Total Anti-HBc was detected in 43.3% of the Anti-HBs reactive population, demonstrating that the immunity against HBV has still been acquired through virus exposure. An intermediate HBsAg seroprevalence of 6.0% was observed with a significant decrease from 12.3% to 5.0% from 2000 to 2010. Anti-HBe positive infections were more frequent than those with HBe antigenemia (77.1% vs. 18.5%) with a notable increase from 2000 to 2003. HBV DNA was detected in 23.6-25.6% with serological markers of viral replication and was more prevalent in HBeAg positive individuals in parallel with AST, ALT and GGT levels. Evidence for horizontal transfer as the major transmission route was revealed with a reduction of childhood HBV infections, attributable to the ongoing vaccination efforts
Disciplinas: Medicina
Palabras clave: Gastroenterología,
Epidemiología,
Virus de la hepatitis B,
Transmisión horizontal,
Vacunación,
Serología,
Hepatitis B
Keyword: Gastroenterology,
Epidemiology,
Hepatitis B virus,
Horizontal transmission,
Vaccination,
Serology,
Hepatitis B
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