Effect of entecavir on CD4+ T-cell subpopulations in patients with chronic hepatitis B



Título del documento: Effect of entecavir on CD4+ T-cell subpopulations in patients with chronic hepatitis B
Revue: Annals of hepatology
Base de datos: PERIÓDICA
Número de sistema: 000409075
ISSN: 1665-2681
Autores: 1
1
1
1
1
Instituciones: 1Third Military Medical University, Southwest Hospital, Shapingba, Chongqing. China
Año:
Volumen: 15
Número: 2
Paginación: 174-182
País: México
Idioma: Inglés
Tipo de documento: Artículo
Enfoque: Aplicado, descriptivo
Resumen en inglés CD4+ T cells play an important role in response to hepatitis B virus (HBV) infection. We investigated the change in CD4+ T-cell subpopulations and viral load in patients with chronic HBV infection who were treated with entecavir. Thirty patients with chronic HBV infection were enrolled according to the criteria recommended by the Chinese Society of Infectious Diseases and the Chinese Society of Hepatology. The expressions of signature transcription factors and cytokines of CD4+ T-cell subpopulations were measured in chronic hepatitis B (CHB) patients treated with entecavir treatment. Results. Results. Entecavir treatment significantly attenuated hepatitis B virus DNA load and affected the CD4+ T-cell subsets in CHB patients. A dramatic decrease in the Th17 and Treg cell frequencies and expressions of their related cytokines were found in CHB patients with entecavir treatment. In contrast, entecavir treatment caused a remarkable increase in the Th2 cell frequencies and expressions of their related cytokines. Our results suggested that Th17 and Treg cells were the more sensitive subtypes to entecavir-induced inhibition of HBV replication compared to Th1 and Th2 cells in chronic HBV patients
Disciplinas: Medicina
Palabras clave: Farmacología,
Gastroenterología,
Virus de la hepatitis B,
Hepatitis crónica,
Terapia antiviral,
Entecavir,
Células T,
Carga viral
Keyword: Medicine,
Gastroenterology,
Pharmacology,
Hepatitis B virus,
Chronic hepatitis,
Antiviral therapy,
Entecavir,
T cells,
Viral load
Texte intégral: Texto completo (Ver PDF)