| Revue: | Annals of hepatology |
| Base de datos: | PERIÓDICA |
| Número de sistema: | 000413463 |
| ISSN: | 1665-2681 |
| Autores: | Tomich, Lisia Gomes Martins de Moura1 Núñez, Marina2 Mendes-Correa, Maria Cassia1 |
| Instituciones: | 1Universidade de Sao Paulo, Hospital das Clinicas, Sao Paulo. Brasil 2Wake Forest University, Health Sciences, Winston-Salem, Carolina del Norte. Estados Unidos de América |
| Año: | 2015 |
| Periodo: | Nov-Dic |
| Volumen: | 14 |
| Número: | 6 |
| Paginación: | 888-894 |
| País: | México |
| Idioma: | Inglés |
| Tipo de documento: | Artículo |
| Enfoque: | Analítico, descriptivo |
| Resumen en inglés | The evaluation of liver disease in HIV patients is cumbersome because may result from a number of different causes. The aim of this retrospective study was to estimate the incidence of severe drug induced liver injury (DILI) in a group of HIV inpatients and investigate potential risk factors. Material and methods. We performed a retrospective analysis of data from HIV-infected patients hospitalized between August 2010 and August 2011 in a tertiary hospital in São Paulo, Brazil. Severe hepatotoxicity was defined as grade 3 (5.1 to 10 x ULN) or 4 (> 10 x ULN) of ALT and AST levels. Factors analyzed included demographics, infection with hepatitis viruses, alcohol history and use of hepatotoxic drugs prior to or during hospital admission. Results. A total of 149 patients with HIV were hospitalized during the study period. The majority were male over 42 years of age and 82 (55%) were taking HAART initiated prior to admission. Mean CD4 counts were 164 cells/mm3. Thirty three patients (22.1%) developed severe DILI during hospital stay, which had a mean duration of 26 days. Factors associated with severe DILI in the multivariate analysis were abnormal baseline ALT levels [OR 2.02 (95%CI 1.13-3.59); p = 0.017] and tuberculosis therapy [OR 2.31 (95% CI 1.27-4.19); p = 0.006]. In conclusion, in this group of HIV patients admitted to a tertiary hospital in Brazil, we found a high incidence (22.1%) of severe DILI. The use of anti-tuberculosis drugs and baseline liver injury were independent factors associated with severe DILI during hospital stay |
| Disciplinas: | Medicina |
| Palabras clave: | Farmacología, Gastroenterología, Inmunología, VIH, Tuberculosis, Hepatotoxicidad, Fármacos, Infecciones oportunistas, Daño hepático |
| Keyword: | Medicine, Gastroenterology, Pharmacology, Immunology, HIV, Tuberculosis, Hepatotoxicity, Drugs, Opportunistic infections, Liver damage |
| Texte intégral: | Texto completo (Ver PDF) |
