| Revue: | Annals of hepatology |
| Base de datos: | PERIÓDICA |
| Número de sistema: | 000413453 |
| ISSN: | 1665-2681 |
| Autores: | Satapathy, Sanjaya K1 Kuwajima, Vanessa1 Nadelson, Jeffrey1 Atiq, Omair2 Sanyal, Arun J3 |
| Instituciones: | 1University of Tennessee, Health Sciences Center, Memphis, Tennessee. Estados Unidos de América 2University of Texas Southwestern, Dallas, Texas. Estados Unidos de América 3Virginia Commonwealth University Health System, Division of Gastroenterology, Hepatology and Nutrition, Richmond, Virginia. Estados Unidos de América |
| Año: | 2015 |
| Periodo: | Nov-Dic |
| Volumen: | 14 |
| Número: | 6 |
| Paginación: | 789-806 |
| País: | México |
| Idioma: | Inglés |
| Tipo de documento: | Artículo |
| Enfoque: | Analítico, descriptivo |
| Resumen en inglés | Over the past decades, many drugs have been identified, that can potentially induce steatohepatitis in the predisposed individual. Classically this has been incriminated to amiodarone, perhexiline, and 4,4’-diethylaminoethoxyhexestrol (DH), all of which have been found to independently induce the histologic picture of non-alcoholic steatohepatitis (NASH). Pathogenetic mechanisms of hepatotoxicity although still evolving, demonstrate that mitochondrial dysfunction, deranged ATP production and fatty acid catabolism likely play an important role. Drugs like steroid hormones can exacerbate the pathogenetic mechanisms that lead to NASH, and other drugs like tamoxifen, cisplatin and irenotecan have been shown to precipitate latent fatty liver as well. Further research aiming to elucidate the pathogenesis of drug-induced steatosis and steatohepatitis is needed in order to better design therapeutic targets |
| Disciplinas: | Medicina |
| Palabras clave: | Farmacología, Gastroenterología, Fármacos, Hepatotoxicidad, Hígado graso no alcohólico, Esteatohepatitis no alcohólica, Resistencia a la insulina, Cirrosis |
| Keyword: | Medicine, Gastroenterology, Pharmacology, Drugs, Hepatotoxicity, Non alcoholic fatty liver, Non-alcoholic steatohepatitis, Insulin resistance, Cirrhosis |
| Texte intégral: | Texto completo (Ver PDF) |
